F3393

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit

fractionated antiserum, lyophilized powder

• Sinônimo(s): Anti-FGF2, Anti-bFGF
• Número MDL: MFCD01322020
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 200
• conjugado: unconjugated
• forma do anticorpo: fractionated antiserum
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: lyophilized powder
• reatividade de espécies: human, bovine, rat
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 1:1,000
• Impurezas: endotoxin, tested
• nº de adesão UniProt: P09038
• aplicação(ões): research pathology
• temperatura de armazenamento: 2-8°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: bovine ... FGF2(281161) ; human ... FGF2(2247) ; rat ... Fgf2(54250)

Descrição

Descrição geral

Fibroblast growth factor-basic (FGFb), also known as NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6) is encoded by the gene mapped to human chromosome 4q28.1. The FGFb gene spanning 34271 bp on genomic DNA contains 16 exons and six introns. FGFb RNA transcripts are expressed in various human tissues including liver, thymus, spleen, peripheral blood leukocytes, heart skeletal muscle, testis, colon and kidney.

Imunogênio

synthetic peptide sequence corresponding to bovine FGF2 (1-24).

Aplicação

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit has been used in:

• immunohistochemistry
• immunostaining
• immunoblotting

Ações bioquímicas/fisiológicas

Fibroblast Growth Factor Basic (also known as bFGF) is a pleotropic cytokine that that is a potent mitogenic factor. On binding to its cognate receptor tyrosine kinase, FGFR, bFGF is capable of activation of pathways such as MAPK and PI3K and produce cellular effects in varied cell types. Fibroblast Growth Factor-basic is reported to induce proliferation of fibroblasts, differentiation, wound healing and regeneration, limb formation, tissue remodeling and angiogenesis.

forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Nota de análise

Bioactivity: Anti-Fibroblast Growth Factor-Basic (1-24) caused a dose-dependent decrease in the mitogenic activity of FGF-Basic such that a final dilution of 1:50 neutralized the bioactivity of 1 unit of FGF Basic.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)