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EPS002

Sigma-Aldrich

MS-275

A HDAC1 and HDAC3 inhibitor

Sinônimo(s):

MS-275 (Entinostat, SNDX-275), 3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate, N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide

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About This Item

Fórmula empírica (Notação de Hill):
C21H20N4O3
Número CAS:
209783-80-2
Peso molecular:
376.41
Número MDL:
MFCD03453552
Código UNSPSC:
12352200
ID de substância PubChem:
329799578
NACRES:
NA.41

Ensaio

≥99%

solubilidade

DMSO: 38 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2

InChI

1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)

chave InChI

INVTYAOGFAGBOE-UHFFFAOYSA-N

Informações sobre genes

human ... HDAC1(3065) , HDAC10(83933) , HDAC11(79885) , HDAC2(3066) , HDAC3(8841) , HDAC4(9759) , HDAC5(10014) , HDAC6(10013) , HDAC7(51564) , HDAC8(55869) , HDAC9(9734)

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Descrição geral

Preferentially inhibits HDAC1 (IC50=300 nM) over HDAC3 (IC50=8 μM). Has no inhibitory activity towards HDAC8 (IC50>100 μM).

Aplicação

MS-275 has been used as a histone deacetylase-1 inhibitor.

Ações bioquímicas/fisiológicas

HDAC inhibitor; antiproliferative.

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palavra indicadora

Danger

Frases de perigo

H301,H360

Classificações de perigo

Acute Tox. 3 Oral - Repr. 1A

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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