D9150

2,3-Dimethoxy-5-methyl-p-benzoquinone

apoptosis inducer

• Sinônimo(s): Coenzyme Q₀
• Fórmula empírica (Notação de Hill): C₉H₁₀O₄
• Número CAS: 605-94-7
• Peso molecular: 182.17
• Beilstein: 1640422
• Número CE: 210-100-8
• Número MDL: MFCD00001595
• Código UNSPSC: 12352204
• ID de substância PubChem: 24894261
• NACRES: NA.51

Propriedades

• Nível de qualidade: 200
• forma: powder
• pf: 58-60 °C (lit.)
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: COC1=C(OC)C(=O)C(C)=CC1=O
• InChI: 1S/C9H10O4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4H,1-3H3
• chave InChI: UIXPTCZPFCVOQF-UHFFFAOYSA-N

Descrição

Descrição geral

2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q₀ or DMM) is present in all the cells including neural cells.

Aplicação

2,3-Dimethoxy-5-methyl-p-benzoquinone has been used:

• as a tau protein fibrillization inducer to determine the regions of tau involved in the formation of paired helical filaments (PHFs)
• as a component in buffer B for cytochrome oxidation assay with subsaturating light
• in the RPMI-1640 medium for 2,3-bis-(2-methoxy-4-nitro-5-sulphenyl)-(2H)-tetrazolium-5-carboxanilide (XTT) assay to quantify antifungal activity

Coenzyme Q0 inhibits (via radical quenching) reactions of gamma-irradiation induced homolytic cleavage of O-glycoside bonds in polysaccharides. Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cells. It is toxic to other cells such as insulin producing cells.

Ações bioquímicas/fisiológicas

2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q₀) interacts with tau protein and aids in the formation of filamentous structure.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves