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D6140

Sigma-Aldrich

Demeclocycline hydrochloride

powder or crystals, suitable for cell culture

Sinônimo(s):

7-Chloro-6-demethyltetracycline hydrochloride, Demethylchlorotetracycline hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C21H21ClN2O8 · HCl
Número CAS:
64-73-3
Peso molecular:
501.31
Beilstein:
3849198
Número CE:
200-592-2
Número MDL:
MFCD00082371
Código UNSPSC:
12352207
ID de substância PubChem:
24278380
NACRES:
NA.75

Nome do produto

Demeclocycline hydrochloride, powder or crystals

Ensaio

89.5-102.0% anhydrous basis

Formulário

powder or crystals

técnica(s)

cell culture | mammalian: suitable

solubilidade

soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria

Modo de ação

protein synthesis | interferes

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O

InChI

1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1

chave InChI

GVSJQNRGSCOSNJ-KBHRXELFSA-N

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Descrição geral

Chemical structure: tetracycline

Ações bioquímicas/fisiológicas

Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.
Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Warning

Classificações de perigo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
108M4884V
028M4786V
076M4755V
BCBQ0861V
BCBM0381V

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Supelco

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Sigma-Aldrich

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O0500000

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Chlortetracycline hydrochloride BioReagent, suitable for fluorescence, from Streptomyces aureofaciens, ≥85.0% (HPLC)

Sigma-Aldrich

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Supelco

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Supelco

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M Athanassiadis et al.
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There is evidence to suggest that Ledermix, placed as an intervisit root canal dressing, might improve periodontal healing after replantation of avulsed teeth. As a part of a multicenter randomized controlled trial, we aimed to compare the effect of 2
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