D1916

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside

≥98% (HPLC), powder, RNA synthesis inhibitor

• Sinônimo(s): 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, 5,6-Dichlorobenzimidazole riboside, DRB
• Fórmula empírica (Notação de Hill): C₁₂H₁₂Cl₂N₂O₄
• Número CAS: 53-85-0
• Peso molecular: 319.14
• Beilstein: 39123
• Número MDL: MFCD00036785
• Código UNSPSC: 12352200
• eCl@ss: 32151902
• ID de substância PubChem: 24278361
• NACRES: NA.77

Propriedades

• Nome do produto: 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside,
• Formulário: powder
• Nível de qualidade: 200
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3cc(Cl)c(Cl)cc23
• InChI: 1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
• chave InChI: XHSQDZXAVJRBMX-DDHJBXDOSA-N
• Informações sobre genes: human ... CSNK2A1(1457) , CSNK2B(1460)

Descrição

Aplicação

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside has been used:

• as an inhibitor of RNA polymerase II in mouse melanoma cells
• for the inhibition of cyclin D1 mRNA synthesis in human prostate epithelial cell lines
• in the inhibition of interleukin-2 gene transcription in Jurkat cells

Ações bioquímicas/fisiológicas

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), a nucleoside analog that halts mRNA synthesis by phosphorylation of the C-terminal domain of RNA polymerase II, making it inactive. It also interferes with the DNA topoisomerase II, may modulate response to cytokines and blocks the human immunodeficiency virus (HIV) via RNA modification. It also inhibits cyclin-dependent kinases (CDKs) 7 and 9 and favors apoptosis in leukemic cells. It may serve as a therapeutic agent in treating cancer.

Inhibitor of RNA synthesis; causes premature termination of transcription. CK2 (casein kinase-2) inhibitor.

Características e benefícios

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Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable