D0899

Diazepam

≥98% (TLC), powder, GABAA receptor ligand

• Sinônimo(s): 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one, Ro 5-2807
• Fórmula empírica (Notação de Hill): C₁₆H₁₃ClN₂O
• Número CAS: 439-14-5
• Peso molecular: 284.74
• Número CE: 207-122-5
• Número MDL: MFCD00057323
• Código UNSPSC: 12352200
• ID de substância PubChem: 24893306
• NACRES: NA.77

Propriedades

• Nome do produto: Diazepam,
• Formulário: powder
• controle de medicamentos: USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• solubilidade: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL; DMF: soluble; H₂O: slightly soluble; ethanol: soluble
• originador: Roche
• cadeia de caracteres SMILES: CN1C(=O)CN=C(c2ccccc2)c3cc(Cl)ccc13
• InChI: 1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
• chave InChI: AAOVKJBEBIDNHE-UHFFFAOYSA-N
• Informações sobre genes: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879) ; rat ... Gabra1(29705) , Gabra2(29706)

Descrição

Aplicação

Diazepam has been used:

• as an anxiolyte in pilocarpine protocol.
• in multi-electrode array (MEA) technology
• as a marker for human serum albumin

Ações bioquímicas/fisiológicas

Anxiolytic; ligand for the GABA_A receptor benzodiazepine modulatory site.

Diazepam is a benzodiazepine anxiolytic agent. It serves as a prototype ligand for the GABAA receptor benzodiazepine modulatory site.

Diazepam is often used as a sedative. Its metabolism involves cytochrome P450 (CYP) 2C19 and 3A4. Diazepam has immediate action upon administration.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS06,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H301 + H311,H410
• Declarações de precaução: P264 - P273 - P280 - P301 + P310 - P302 + P352 + P312 - P361 + P364
• Classificações de perigo: Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 1
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves