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Key Documents

PHR1768

Supelco

Dexamethasone Sodium Phosphate

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

Dexamethasone 21-phosphate disodium salt, 9-Fluoro-11b,17, 21-trihydroxy-16α- methylpregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate) disodium salt

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About This Item

Fórmula empírica (Notação de Hill):
C22H28FNa2O8P
Número CAS:
Peso molecular:
516.40
Beilstein:
6473066
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to BP 108
traceable to Ph. Eur. D0720000
traceable to USP 1177032

família API

dexamethasone

Certificado de análise (CofA)

current certificate can be downloaded

embalagem

pkg of 1 g

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1

chave InChI

PLCQGRYPOISRTQ-FCJDYXGNSA-L

Informações sobre genes

human ... NR3C1(2908)

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Categorias relacionadas

Descrição geral

Dexamethasone is a glucocorticoid and an anti-inflammatory agent, widely used in ocular inflammatory diseases.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

Dexamethasone Sodium Phosphate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using differential pulse polarography technique and high-performance liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC1690 in the slot below. This is an example certificate only and may not be the lot that you receive.

produto relacionado

Nº do produto
Descrição
Preços

Pictogramas

Health hazardExclamation mark

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

Classificações de perigo

Acute Tox. 4 Oral - Repr. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Trace determination of dexamethasone sodium phosphate in pharmaceutical formulations by differential pulse polarography
Jeyaseelan C and Joshi PA
Analytical and Bioanalytical Chemistry, 373(8), 772-776 (2002)
Simultaneous determination of gatifloxacin and dexamethasone sodium phosphate in bulk and pharmaceutical formulations by HPLC
Sireesha RK, et al.
African Journal of Pharmacy and Pharmacology, 5(17), 1990-1995 (2011)
Tzu-Chieh Chen et al.
The Journal of biological chemistry, 294(23), 9213-9224 (2019-05-06)
Chronic or excess glucocorticoid exposure causes lipid disorders such as hypertriglyceridemia and hepatic steatosis. Angptl4 (angiopoietin-like 4), a primary target gene of the glucocorticoid receptor in hepatocytes and adipocytes, is required for hypertriglyceridemia and hepatic steatosis induced by the synthetic

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