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C8138

Sigma-Aldrich

Chlorpromazine hydrochloride

≥98% (TLC), powder, D2 dopamine receptor antagonist

Sinônimo(s):

2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil

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About This Item

Fórmula empírica (Notação de Hill):
C17H19ClN2S · HCl
Número CAS:
69-09-0
Peso molecular:
355.33
Beilstein:
3779989
Número CE:
200-701-3
Número MDL:
MFCD00012654
Código UNSPSC:
12352200
ID de substância PubChem:
57654045
NACRES:
NA.77

product name

Chlorpromazine hydrochloride, ≥98% (TLC)

Nível de qualidade

200

Ensaio

≥98% (TLC)

forma

powder

pf

194-196 °C

solubilidade

water: 50 mg/mL

originador

GlaxoSmithKline

cadeia de caracteres SMILES

Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

chave InChI

FBSMERQALIEGJT-UHFFFAOYSA-N

Informações sobre genes

human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HRH1(3269) , HTR2A(3356)

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Aplicação

Chlorpromazine hydrochloride has been used:
  • as an antagonists for calmodulin kinase
  • as a medium supplement to test its cytotoxic effects in human lung microvascular endothelial cells (HMVEC-L)
  • as an inhibitor of clathrin-mediated endocytosis in RAW 264.7 cells

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

Ações bioquímicas/fisiológicas

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.
Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Características e benefícios

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301,H330

Classificações de perigo

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Endocytic pathways used by Andes virus to enter primary human lung endothelial cells
Chiang CF, et al.
PLoS ONE, 11(10), e0164768-e0164768 (2016)
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Nano-micro letters, 12(1), 90-90 (2020-04-13)
Because of enhanced efficacy and lower side effects, cancer immunotherapies have recently been extensively investigated in clinical trials to overcome the limitations of conventional cancer monotherapies. Although engineering attempts have been made to build nanosystems even including stimulus nanomaterials for
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Journal of neurophysiology, 97(3), 2465-2479 (2007-03-14)
The translation of prior activity into changes in excitability is essential for memory and the initiation of behavior. After brief synaptic input, the bag cell neurons of Aplysia californica undergo a nearly 30-min afterdischarge to release egg-laying hormone. The present
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Enteroviruses are a major cause of human disease. Adipose-specific phospholipase A2 (PLA2G16) was recently identified as a pan-enterovirus host factor and potential drug target. In this study, we identify a possible mechanism of PLA2G16 evasion by employing a dual glycan
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