C4899
Carnitine Acetyltransferase from pigeon breast muscle
ammonium sulfate suspension, ≥50 units/mg protein
Sinônimo(s):
CATC, Carnitine acetyltransferase, Acetyl-Co-A:carnitine-O-acetyltransferase, CrAT
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About This Item
Número CAS:
Número MDL:
Código UNSPSC:
12352204
NACRES:
NA.54
Produtos recomendados
fonte biológica
pigeon breast
Nível de qualidade
forma
ammonium sulfate suspension
atividade específica
≥50 units/mg protein
concentração
≥0.4 mg/mL
técnica(s)
cell based assay: suitable
nº de adesão de ID de proteína
nº de adesão UniProt
temperatura de armazenamento
2-8°C
Informações sobre genes
pigeon ... CRAT(102084317)
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Descrição geral
Research area: Cell Signaling
Aplicação
Carnitine Acetyltransferase from pigeon breast muscle has been used in enzymatic assays.
Ações bioquímicas/fisiológicas
Carnitine acyltransferases (CrAT) are enzymes that contribute to the reversible conversion of acetyl-CoA and carnitine into acetylcarnitine and free CoA. This enzymatic process plays a vital role in the energy metabolism of eukaryotes by promoting the β-oxidation of fatty acids. CrAT-mediated acetyl carnitine production and efflux help maintain a balance between acetyl-CoA and acetyl carnitine in the mitochondria, regenerate free CoA, and alleviate the product inhibition of pyruvate dehydrogenase (PDH), which is a key enzyme in glucose oxidation. This process promotes glucose homeostasis and helps maintain optimal cellular energy metabolism. Carnitine acetyltransferase activity also aids in the progression of the cell cycle from G1 to S phase. carnitine acetyltransferase deficiency also leads to the development of various neurological disorders including Alzheimer′s disease, ataxic encephalopathy, and several vascular diseases.
Carnitine acetyltransferase maintains the cellular and mitochondrial levels of acetyl-CoA, a key cofactor required for oxidative metabolism, by catalyzing an equilibrium between acetyl-CoA and acetyl-L-carnitine, a storage form of activated acetate. Carnitine acetyltransferase also maintains the pool of acetyl-CoA required for neuronal and nonneuronal acetylcholine production.
Definição da unidade
One unit will convert 1.0 μmole of acetyl-L-carnitine and CoA to L-carnitine and acetyl-CoA per min at pH 8.0 at 25 °C.
forma física
Crystalline suspension in 3.2 M (NH4)2SO4 solution, 50 mM potassium phosphate, 1 mM dithiothreitol, pH 7.0
Nota de análise
Protein determined by biuret.
inibidor
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Artigos
Instructions for working with enzymes supplied as ammonium sulfate suspensions
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