C2436
Cytochrome c from Saccharomyces cerevisiae
≥85% based on Mol. Wt. 12,588 basis
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About This Item
Produtos recomendados
fonte biológica
Saccharomyces cerevisiae
Nível de qualidade
Ensaio
≥85% based on Mol. Wt. 12,588 basis
Formulário
powder
peso molecular
12,588 Da
técnica(s)
cell based assay: suitable
solubilidade
water: 10 mg/mL, clear, red to red-brown (dark red)
nº de adesão UniProt
aplicação(ões)
cell analysis
temperatura de armazenamento
−20°C
Informações sobre genes
Saccharomyces cerevisiae ... CYC1(853507)
Descrição geral
Cytochrome c (Cytc) comprises 104 amino acids and is a nuclear-encoded mitochondrial protein. This peripheral membrane protein is in spherical shape and has a molecular weight of 12,000 Da.
Aplicação
Cytochrome c from Saccharomyces cerevisiae has been used in oocyte injection to induce caspase-3 activation and p38 MAPK (mitogen-activated protein kinase). It has also been used to analyze the aerobic reactions of nitric oxide.
Ações bioquímicas/fisiológicas
Cytochrome c (Cytc) participates in mitochondrial electron transport and intrinsic type II apoptosis. It plays a key role in aerobic energy production. This multi-functional enzyme serves as a single electron carrier. Cytc helps in the formation of the apoptosome.
The ready fluctuation of cytochrome c within the cell between ferrous and ferric states, makes it an efficient biological electron-transporter. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal catalyst of respiration, it forms the essential electron-bridge between the respirable substrates and oxygen. Tracking cellular localization of cytochrome c in S. cerervisiae demonstrates that mitochondria are strongly involved in programmed cell death, a process very similar to apoptosis in higher organisms.
Qualidade
Care has been taken to maintain the native form of the protein. It has not been artificially oxidized or reduced during purification. Contains variable amounts of reduced cytochrome c.
Nota de preparo
Prepared without using TCA.
Outras notas
View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.
Aplicação
Nº do produto
Descrição
Preços
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitrite
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The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: from respiration to apoptosis
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Artigos
Learn about the four membrane-bound protein complexes that make up the electron transport chain metabolic pathway supplying energy as ATP for cellular respiration.
Chromatograms
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