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Key Documents

PHR1590

Supelco

Bacitracin

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

Bacitracin

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About This Item

Fórmula empírica (Notação de Hill):
C66H103N17O16S
Número CAS:
Peso molecular:
1422.69
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to USP 1048007

família API

bacitracin

Certificado de análise (CofA)

current certificate can be downloaded

embalagem

pkg of 1 g

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

pf

221-225 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

-10 to -25°C

cadeia de caracteres SMILES

CCC(C)C(N)C1=NC(CS1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]2CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC2=O)[C@@H](C)CC

InChI

1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-/m0/s1

chave InChI

CLKOFPXJLQSYAH-RNHDWVCBSA-N

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Descrição geral

Bacitracin is a polypeptide antibiotic recovered from certain strains of B. subtilis and B. licheniformis. Its mode of action involves the inhibition of bacterial cell wall synthesis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

Bacitracin may be used as a pharmaceutical secondary reference standard for the determination of the analyte in serum samples and food samples by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAA4581 in the slot below. This is an example certificate only and may not be the lot that you receive.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Supelco

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Sigma-Aldrich

94747

Vancomicina

Bacitracin: a new antibiotic produced by a member of the B. subtilis group
Johnson BA, et al.
Science (New York, N.Y.), 102(2650), 376-377 (1945)
Analysis of major components of residual bacitracin and colistin in food samples by liquid chromatography tandem mass spectrometry
Sin DW, et al.
Analytica Chimica Acta, 535(1-2), 23-31 (2005)
Bacitracin: an inhibitor of the dephosphorylation of lipid pyrophosphate, an intermediate in the biosynthesis of the peptidoglycan of bacterial cell walls
Siewert G and Strominger JL
Proceedings of the National Academy of Sciences of the USA, 57(3), 767-767 (1967)
Determination of neomycin and bacitracin in human or rabbit serum by HPLC--MS/MS
Mascher DG, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(2), 691-700 (2007)

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