B4186

Butyrylcholinesterase human

vial of ≥4 units

• Sinônimo(s): Acylcholine acyl-hydrolase, Choline esterase, butyryl, Pseudocholinesterase
• Número CAS: 9001-08-5
• Número da licença da enzima: 3.1.1.8 (BRENDA, IUBMB)
• Número CE: 232-579-2
• Número MDL: MFCD00081455
• Código UNSPSC: 12352204
• NACRES: NA.54

Propriedades

• forma: powder
• Nível de qualidade: 200
• atividade específica: ≥50 units/mg protein
• embalagem: vial of ≥4 units
• nº de adesão UniProt: P06276
• temperatura de armazenamento: 2-8°C
• Informações sobre genes: human ... BCHE(590)

Descrição

Aplicação

BchE, from Sigma, has been used to determine butyrylcholinesterase inhibition by various test compounds .

Butyrylcholinesterase human has been used to study its role as a modulator of pathological features of Alzheimer′s disease (AD) in vivo.

Ações bioquímicas/fisiológicas

Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. BChE is found in the serum, hemopoietic cells, liver, lung, heart and the central nervous system of vertebrates.

Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. It is found in the serum, hemopoietic cells, liver, lung, heart and the central nervous system of vertebrates. BChE hydrolyzes large esters of choline such as butyrylcholine and benzoylcholine. Selective inhibition of BChE activity can be used in the detection of organophosphates. BchE may be used to treat organophosphate toxicity. It is a critical target for Alzheimer′s disease (AD) therapy.

Definição da unidade

One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.

Nota de análise

Starting material individually donor tested and found negative for HIV I & II antibodies, Hepatitis B surfaceantigen, and Hepatitis C antibodies.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H334
• Declarações de precaução: P261 - P284 - P501
• Classificações de perigo: Resp. Sens. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable