C1057
Butirilcolinesterase
lyophilized powder, ≥900 units/mg protein
Sinônimo(s):
Acilcolina acil-hidrolase, Colina esterase, butiril, Pseudocolinesterase
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About This Item
Produtos recomendados
forma
lyophilized powder
Nível de qualidade
atividade específica
≥900 units/mg protein
peso molecular
tetramer 440 kDa
composição
Protein, ≥10%
solubilidade
H2O: soluble 10 mg/mL
aplicação(ões)
diagnostic assay manufacturing
temperatura de armazenamento
−20°C
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Aplicação
Selective inhibition of BChE activity can be used in the detection of organophosphates. Its use in the treatment of organophosphate toxicity has been explored. It has been reported that the level of BChE in human blood correlates to the degree of protection against potentially toxic nerve agents. Cholinesterases have also been investigated for their role in Alzheimer′s disease.
Ações bioquímicas/fisiológicas
Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities.BChE can, unlike AChE, efficiently hydrolyze larger esters of choline such as butyrylcholine and benzoylcholine. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). The enzyme is activated by Ca2+ and Mg2+. The activity is constant over the pH range of 6.0-8.0. It is inhibited by betaine, nicotine, organophosphates, and carbamate.
Definição da unidade
One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.
forma física
Highly purified; contains buffer salts
Nota de análise
Protein determined by biuret
inibidor
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Resp. Sens. 1
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
Certificados de análise (COA)
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