B3259

Bradykinin acetate salt

powder, ≥98% (HPLC)

• Fórmula empírica (Notação de Hill): C₅₀H₇₃N₁₅O₁₁ · xC₂H₄O₂
• Número CAS: 6846-03-3
• Peso molecular: 1060.21 (free base basis)
• Número CE: 227-781-2
• Código UNSPSC: 12352106
• NACRES: NA.32

Propriedades

• Ensaio: ≥98% (HPLC)
• forma: powder
• condição de armazenamento: desiccated
• cor: white
• solubilidade: 0.1 M acetic acid: 25 mg/mL, clear, colorless
• nº de adesão UniProt: P01042
• temperatura de armazenamento: −20°C
• InChI: 1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
• chave InChI: QXZGBUJJYSLZLT-FDISYFBBSA-N
• Informações sobre genes: human ... KNG1 (includes EG:3827)

Descrição

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

Aplicação

Bradykinin acetate salt has been used:

• to stimulate the contraction of guinea pig ileum
• as a contractile agent in fibroblasts
• In the stimulation of endothelium of human subcutaneous artery
• To evoke Ca²⁺ signals in neuroblastoma-glioma hybrid cell line, NG108-15

Ações bioquímicas/fisiológicas

Bradykinin is a pro-inflammatory peptide that acts through G-protein-coupled receptors. It activates sphingolipid metabolism. Fibroblasts treated with bradykinin produce a rapid and important increase in ceramide which is followed by a transient rise in sphingosine content. The peptide also increases ceramide cellular content by rapidly mobilizing neutral glycolipids. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability. The bradykinin potentiators, which possess no bradykinin activity themselves, enhance the activity of bradykinin.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)