05-23-0500

Bradykinin

Induces the release of nitric oxide.

• Sinônimo(s): Bradykinin, Kallidin, RPPGFSPFR, callidin
• Fórmula empírica (Notação de Hill): C₅₀H₇₃N₁₅O₁₁
• Número CAS: 58-82-2
• Peso molecular: 1060.21
• Número MDL: MFCD00076258
• Código UNSPSC: 12352202
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥97% (HPLC)
• Formulário: lyophilized solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: white to off-white
• solubilidade: 5% acetic acid: 1 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: N2([C@@H](CCC2)C(=O)NCC(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CO)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N
• InChI: 1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
• chave InChI: QXZGBUJJYSLZLT-FDISYFBBSA-N

Descrição

Descrição geral

Bradykinin, a nonapeptide, is produced in plasma under inflammatory conditions by cleavage of kininogen by kallikrein. Bradykinin is involved in a number of physiological functions, including the release of nitric oxide, stimulation of pain receptors, induction of antimitogenic effects, inhibition of cAMP accumulation, induction of smooth muscle contraction, and vasodilation, as well as in inflammation processes. Also involved in edema resulting from trauma or injury. Improves post-ischemic recovery of the heart via a nitric oxide-dependent mechanism.

Aplicação

Bradykininhas been used in studying the changes in colonic afferent response tobradykinin.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
Induces the release of nitric oxide

Product does not compete with ATP.

Reversible: no

Embalagem

Yes

Sequência

H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH

forma física

Supplied as an acetate salt.

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Mombouli, J.V., and Vanhoutte, P.M. 1995. Am. J. Hypertens.8, 195.
Zhu, P., et al. 1995. Cardiovasc. Res.29, 658.
Bedarida, G.V., et al. 1994. Horm. Metab. Res. 26, 109.
Altiok, N., and Fredholm, B.B. 1993. Cell Signal. 5, 279.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable