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Key Documents

B2805

Sigma-Aldrich

BMP6, human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Sinônimo(s):

BMP-6

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About This Item

Número MDL:
MFCD02097809
Código UNSPSC:
12352202
NACRES:
NA.32

product name

Bone Morphogenetic Protein 6 human, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

fonte biológica

human

Nível de qualidade

100

recombinante

expressed in NSO cells

Ensaio

>95% (SDS-PAGE)

forma

lyophilized powder

potência

0.05-0.15 μg/mL ED50

peso molecular

30–38 kDa

embalagem

pkg of 20 μg

condição de armazenamento

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

técnica(s)

cell culture | mammalian: suitable

Impurezas

endotoxin, tested

nº de adesão UniProt

P22004

temperatura de armazenamento

−20°C

Informações sobre genes

human ... BMP6(654)

Ações bioquímicas/fisiológicas

Cellular responses to BMP-6 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. Mature human and murine BMP-6 demonstrates 96% homology.

forma física

Lyophilized from 200 ul 0.2 μm filtered solution in 40% acetonitrile, 0.1% trifluoroacetic acid containing 50ug bovine serum albumin per 1 ug as a carrier protein.

Nota de análise

The biological activity is measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Bone morphogenetic proteins and their receptors: potential functions in the brain.
Ebendal, T., et al
The Journal of Neuroscience, 51, 139-146 (1998)
Christine E McLaren et al.
Hepatology (Baltimore, Md.), 62(2), 429-439 (2015-01-22)
To identify polymorphisms associated with variability of iron overload severity in HFE-associated hemochromatosis, we performed exome sequencing of DNA from 35 male HFE C282Y homozygotes with either markedly increased iron stores (n = 22; cases) or with normal or mildly increased iron
Stephanie Arndt et al.
Gut, 64(6), 973-981 (2014-07-12)
Bone morphogenetic protein 6 (BMP6) has been identified as crucial regulator of iron homeostasis. However, its further role in liver pathology including non-alcoholic fatty liver disease (NAFLD) and its advanced form non-alcoholic steatohepatitis (NASH) is elusive. The aim of this
Hiroshi Kawabata et al.
Experimental hematology, 43(5), 404-413 (2015-01-31)
Hepcidin is the central regulator of systemic iron homeostasis; dysregulation of hepcidin expression causes various iron metabolic disorders, including hereditary hemochromatosis and anemia of inflammation. To identify molecules that modulate hepcidin expression, we developed a bioassay system for hepcidin gene
Zhu Xishan et al.
Journal of experimental & clinical cancer research : CR, 30, 47-47 (2011-05-04)
Overwhelming evidence from leukemia research has shown that the clonal population of neoplastic cells exhibits marked heterogeneity with respect to proliferation and differentiation. There are rare stem cells within the leukemic population that possess extensive proliferation and self-renewal capacity not
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