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H4791

Sigma-Aldrich

Bone Morphogenetic Protein 2 human

BMP-2, recombinant, expressed in HEK 293 cells, HumanKine, suitable for cell culture

Sinônimo(s):

BMP-2

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About This Item

Número MDL:
MFCD03097877
Código UNSPSC:
12352202
NACRES:
NA.77

fonte biológica

human

Nível de qualidade

100

recombinante

expressed in HEK 293 cells

forma

lyophilized powder

potência

≤60 ng/mL EC50

qualidade

endotoxin tested

peso molecular

dimer 30-38 kDa (glycosylated)

embalagem

pkg of 10 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

técnica(s)

cell culture | mammalian: suitable

Impurezas

≤1 EU/μg Endotoxin level

nº de adesão UniProt

P12643

temperatura de armazenamento

−20°C

Informações sobre genes

human ... BMP2(650)

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Descrição geral

Bone Morphogenetic Protein 2 is a member of the TGF-β superfamily of cytokines that affect bone and cartilage formation. It is important for skeletal development during embryogenesis. BMP-2 induces chondrocyte formation, osteoblast differentiation, and is involved in embryo dorsal-ventral patterning and organogenesis.

Ações bioquímicas/fisiológicas

It has been reported that Bone Morphogenetic Protein 2 (BMP-2) inhibits estradiol induced proliferation of human breast cancer cells. BMP-2 signaling mediates apoptosis by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. Cellular responses to BMP-2 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors, which play significant roles in BMP binding and signaling. One BMP type II receptor and two BMP type I receptors have been identified. Both BMP type I receptors bind BMP-2 with high-affinity in the absence of BMP receptor type II.

forma física

Lyophilized from a 0.2 μm filtered solution of 2x PBS + 6% Ethanol.

Nota de preparo

This Bone Morphogenetic Protein 2 (BMP-2) is produced from a DNA sequence encoding the human BMP-2 protein, expressed in HEK 293 cells. It is a glycosylated homodimer linked by a single disulfide bond with an apparent molecular mass of 30-38 kDa.

Nota de análise

The specific activity was determined by its ability to induce alkaline phosphatase production in a dose response to BMP-2 in the ATDC-5 cell line (mouse chondrogenic cell line).

Informações legais

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Moulay Hicham Alaoui-Ismaili et al.
Cytokine & growth factor reviews, 20(5-6), 501-507 (2009-11-17)
Bone morphogenetic proteins (BMPs) are growth factors belonging to the TGF beta super family. To date, more than twenty human BMPs have been identified. Of these, BMP-2 and BMP-7 (also known as osteogenic protein 1 or OP-1) are the only
Ernst B Hunziker et al.
Tissue engineering. Part A, 21(13-14), 2089-2098 (2015-04-22)
The articular cartilage layer of synovial joints is commonly lesioned by trauma or by a degenerative joint disease. Attempts to repair the damage frequently involve the performance of autologous chondrocyte implantation (ACI). Healthy cartilage must be first removed from the
Fengxuan Han et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(7), 1344-1353 (2014-11-12)
Repair of cartilage-bone interface tissue remains challenging, because it combines different cell types and gradients of composition and properties. To enable simultaneous regeneration of bone, cartilage, and especially their interface, a conically graded scaffold of chitosan-gelatin hydrogel/poly(l-lactide-co-glycolide) (PLGA) was facilely
Bo Shuai et al.
BMC complementary and alternative medicine, 15, 250-250 (2015-07-25)
Qing'e formula (QEF), prepared from an ancient Chinese recipe, was previously suggested to regulate bone metabolism and improve bone mineral density in patients with osteoporosis. To study the effects of medicated serum containing QEF on the in vitro differentiation of
Thorsten Pfirrmann et al.
Human molecular genetics, 24(11), 3119-3132 (2015-02-26)
Chordin-Like 1 (CHRDL1) mutations cause non-syndromic X-linked megalocornea (XMC) characterized by enlarged anterior eye segments. Mosaic corneal degeneration, presenile cataract and secondary glaucoma are associated with XMC. Beside that CHRDL1 encodes Ventroptin, a secreted bone morphogenetic protein (BMP) antagonist, the
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