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SAB4502954

Sigma-Aldrich

Anti-TGF β1 antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

CED, DPD1, TGF-β 1, diaphyseal dysplasia 1, progressive

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen 44 kDa

reatividade de espécies

mouse, rat, human

concentração

~1 mg/mL

técnica(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

nº de adesão NCBI

P01137

nº de adesão UniProt

P01137

aplicação(ões)

research pathology

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... TGFB1(7040)

Descrição geral

Anti-TGF β1 Antibody detects endogenous levels of total TGF β1 protein.
The TGF β1 (transforming growth factor β1) gene is mapped to human chromosome 19q13.2.

Imunogênio

The antiserum was produced against synthesized peptide derived from human TGF beta1.

Immunogen Range: 336-385

Aplicação

Anti-TGF β1, C-Terminal antibody produced in rabbit has been used in immunohistochemistry and Western blot analysis.

Ações bioquímicas/fisiológicas

TGF β1 (transforming growth factor β1) mediates cell vitality, proliferation, epithelial–mesenchymal transition and promotes angiogenesis. TGF β1 controls the process of apoptosis, organ development and bone formation.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sheng Zhao et al.
Theranostics, 11(18), 8660-8673 (2021-09-16)
Rationale: Ureteral obstruction-induced hydronephrosis is associated with renal fibrosis and progressive chronic kidney disease (CKD). Exosome-mediated cell-cell communication has been suggested to be involved in various diseases, including renal fibrosis. However, little is known regarding how exosomes regulate renal fibrosis
CD44v6 promotes ?-catenin and TGF-? expression, inducing aggression in ovarian cancer cells.
Wang J
Molecular Medicine Reports, 11(5), 3505-3510 (2015)
Loss-of-function of miR-142 by hypermethylation promotes TGF-?-mediated tumour growth and metastasis in hepatocellular carcinoma.
Yu Q
Cell Proliferation, 50(6) (2017)
Fucoidan exerts protective effects against diabetic nephropathy related to spontaneous diabetes through the NF-?B signaling pathway in vivo and in vitro.
Wang Y
International Journal of Molecular Medicine, 35(4), 1067-1073 (2015)
Analysis of polymorphic TGFB1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults.
Stoll C
BMC Medical Genetics, 5:15, 1-9 (2004)
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