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B2185

Bisoprolol hemifumarate salt

Name: Bisoprolol hemifumarate salt
Brand: SIGMA

≥98% (HPLC), solid

Sinônimo(s):

1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate salt

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About This Item

Fórmula empírica (Notação de Hill):

C₁₈H₃₁NO₄ · .5C₄H₄O₄

Número CAS:

104344-23-2

Peso molecular:

383.48

Número MDL:

MFCD00792743

Código UNSPSC:

12352200

ID de substância PubChem:

24724414

NACRES:

NA.77

Ensaio

≥98% (HPLC)

forma

solid

cor

white

solubilidade

DMSO: >20 mg/mL

originador

Teva

cadeia de caracteres SMILES

OC(=O)\C=C\C(O)=O.CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1.CC(C)NCC(O)COc2ccc(COCCOC(C)C)cc2

InChI

1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+

chave InChI

VMDFASMUILANOL-WXXKFALUSA-N

Informações sobre genes

human ... ADRB1(153)

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Aplicação

Bisoprolol hemifumarate salt has been used as a β-adrenergic receptor (β-AR) antagonist in cardiac fibrosis mice model.

Ações bioquímicas/fisiológicas

Bisoprolol hemifumarate is useful in oral formulations due to its high bioavailability. It also shows long elimination half-life.

Cardioselective β₁-adrenoceptor antagonist.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

GHS08,GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H361fd,H373

Declarações de precaução

P202 - P260 - P264 - P280 - P301 + P312 - P308 + P313

Classificações de perigo

Acute Tox. 4 Oral - Repr. 2 - STOT RE 2

Órgãos-alvo

Heart

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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Pharmacokinetics and metabolism of bisoprolol enantiomers in humans

Horikiri Y, et al.

Journal of Pharmaceutical Sciences, 87(3), 289-294 (1998)

Assessment of beta-adrenoceptor selectivity of a new beta-adrenoceptor antagonist, bisoprolol, in man.

A E Tattersfield et al.

British journal of clinical pharmacology, 18(3), 343-347 (1984-09-01)

Bisoprolol is a new beta-adrenoceptor antagonist which has shown beta-adrenoceptor selectivity in studies in isolated tissues. Bronchial and cardiac beta-adrenoceptor blockade were assessed in eight normal subjects before and after oral ingestion of placebo, bisoprolol 20 and 40 mg, metoprolol

Regulation of cyclic adenosine monophosphate release by selective β2-adrenergic receptor stimulation in human terminal failing myocardium before and after ventricular assist device support.

Astrid Kassner et al.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 31(10), 1127-1135 (2012-09-15)

Response to catecholamines is blunted in terminal heart failure due to β-receptor downregulation and uncoupling from adenylyl cyclase (AC). Improved myocardial responsiveness to catecholamines after ventricular assist device (VAD) support is associated with upregulation of β1-adrenergic receptors (β1-ARs). Little is

Feasibility of landiolol and bisoprolol for prevention of atrial fibrillation after coronary artery bypass grafting: a pilot study.

Akira Sezai et al.

The Journal of thoracic and cardiovascular surgery, 144(5), 1241-1248 (2012-08-04)

We previously performed a trial of intravenous landiolol hydrochloride during and after cardiac surgery (the PASCAL trial) and demonstrated a preventive effect on postoperative atrial fibrillation (AF). In the present study, we investigated the efficacy of increasing the dose and

[Takotsubo cardiomyopathy: a novel beta-adrenergic blocker withdrawal syndrome].

János Tomcsányi et al.

Orvosi hetilap, 154(7), 267-271 (2013-02-12)

The authors describe two cases of takotsubo cardiomyopathy developing after an abrupt withdrawal of carvedilol and bisoprolol. Takotsubo or stress cardiomyopathy is characterized by acute and reversible cardiac dysfunction without coronary artery disease. It is triggered by acute emotional or

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