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L9908

LY-294,002 hydrochloride

Name: LY-294,002 hydrochloride
Brand: SIGMA

from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor

Sinônimo(s):

2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):

C₁₉H₁₇NO₃ · HCl

Número CAS:

934389-88-5

Peso molecular:

343.80

Número MDL:

MFCD00270881

Código UNSPSC:

12352207

ID de substância PubChem:

24278828

NACRES:

NA.77

product name

LY-294,002 hydrochloride, solid, ≥98% (HPLC)

fonte biológica

microbial (Staphylococcus roseus)

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

cor

white to off-white

solubilidade

DMSO: >5 mg/mL
H₂O: insoluble

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4

InChI

1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2

chave InChI

CZQHHVNHHHRRDU-UHFFFAOYSA-N

Descrição geral

LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.

Aplicação

LY-294,002 hydrochloride has been used in the inhibition of:

phosphoinositide 3-kinase (PI3K) in human lung cancer cell line
autophagy in mesenchymal stem cells (MSCs).
serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.

Ações bioquímicas/fisiológicas

Specific cell permeable phosphatidylinositol 3-kinase inhibitor.

Características e benefícios

This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Carboxyl-Terminal Modulator Protein Ameliorates Pathological Cardiac Hypertrophy by Suppressing the Protein Kinase B Signaling Pathway

Liu X, et al.

Journal of the American Heart Association, 7(13), e008654-e008654 (2018)

Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine

Walker EH, et al.

Molecular Cell, 6(4), 909-919 (2000)

Regulation of PKCbeta levels and autophagy by PML is essential for high-glucose-dependent mesenchymal stem cell adipogenesis

Morganti C, et al.

International Journal of Obesity, 1-1 (2018)

Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase.

C J Vlahos et al.

Journal of immunology (Baltimore, Md. : 1950), 154(5), 2413-2422 (1995-03-01)

Neutrophils contain a multicomponent NADPH oxidase system that is involved in the production of microbicidal oxidants. Stimulation of human neutrophils with the peptide FMLP activates this respiratory burst enzyme to produce superoxide and also has been shown to result in

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

G J Brunn et al.

The EMBO journal, 15(19), 5256-5267 (1996-10-01)

The immunosuppressant, rapamycin, inhibits cell growth by interfering with the function of a novel kinase, termed mammalian target of rapamycin (mTOR). The putative catalytic domain of mTOR is similar to those of mammalian and yeast phosphatidylinositol (PI) 3-kinases. This study

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