A7902

2-Amino-2-norbornanecarboxylic acid

suitable for ligand binding assays

• Sinônimo(s): BCH, 2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid
• Fórmula empírica (Notação de Hill): C₈H₁₃NO₂
• Número CAS: 20448-79-7
• Peso molecular: 155.19
• Número MDL: MFCD00167580
• Código UNSPSC: 12352106
• ID de substância PubChem: 24891291
• NACRES: NA.26

Propriedades

• product name: 2-Amino-2-norbornanecarboxylic acid, amino acid transport inhibitor
• forma: powder
• técnica(s): ligand binding assay: suitable
• cor: white to off-white
• pf: >300 °C (lit.)
• cadeia de caracteres SMILES: NC1(C[C@@H]2CC[C@H]1C2)C(O)=O
• InChI: 1S/C8H13NO2/c9-8(7(10)11)4-5-1-2-6(8)3-5/h5-6H,1-4,9H2,(H,10,11)/t5-,6+,8?/m1/s1
• chave InChI: MPUVBVXDFRDIPT-RSHNMJPRSA-N

Descrição

Descrição geral

2-Amino-2-norbornanecarboxylic acid is a potential large amino acid transporters inhibitor. It may suppress tumor progression and apoptosis.

Aplicação

• Thyroid Hormone Transporters in a Human Placental Cell Model.: This study investigates the role of 2-Amino-2-norbornanecarboxylic acid in the transport of thyroid hormones in placental cells, offering insights that could improve understanding of fetal development and maternal health (Chen et al., 2022).


• Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2.: Research explores how 2-Amino-2-norbornanecarboxylic acid affects metabolic responses to hypoxia in neonatal brain development, providing a foundation for future studies on brain health and neurodevelopment (Fitzgerald et al., 2021).


• Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis.: This article assesses the potential of 2-Amino-2-norbornanecarboxylic acid as a selective inhibitor that could lead to new treatments for cancer while preserving critical brain functions (Markowicz-Piasecka et al., 2020).


• Regulation of Melanogenesis by the Amino Acid Transporter SLC7A5.: Research demonstrates the utility of 2-Amino-2-norbornanecarboxylic acid in regulating skin pigmentation processes, which could have implications for disorders related to pigmentation (Gaudel et al., 2020).


• Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex.: This study utilizes 2-Amino-2-norbornanecarboxylic acid to elucidate the structure of a key amino acid transporter, which is crucial for understanding nutrient uptake and its implications in various diseases (Yan et al., 2019).

Ações bioquímicas/fisiológicas

2-Amino-2-norbornanecarboxylic acid (BCH) is a Na(+)-independent system L specific substrate used with other system specific substrates such as the system A specific substrate α-(methylamino) isobutyric acid and system N specific substrate L-glutamic acid gamma-monohydroxamate to help identify, differentiate and characterize amino acid transport systems in cells.

Qualidade

Mixture of exo- and endo-isomers.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable