D2926

Diphenyleneiodonium chloride

≥98%

• Sinônimo(s): DPI, Dibenziodolium chloride
• Fórmula empírica (Notação de Hill): C₁₂H₈ClI
• Número CAS: 4673-26-1
• Peso molecular: 314.55
• Número MDL: MFCD00214165
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278032
• NACRES: NA.77

Propriedades

• Nível de qualidade: 300
• Ensaio: ≥98%
• Formulário: powder
• pf: 278 °C
• solubilidade: DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: [Cl-].[I+]1c2ccccc2-c3ccccc13
• InChI: 1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1
• chave InChI: FCFZKAVCDNTYID-UHFFFAOYSA-M
• Informações sobre genes: human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846) ; mouse ... Pik3r1(18708)

Descrição

Aplicação

Diphenyleneiodonium chloride has been used as an NOX inhibitor:

• to study its effects on the reactive oxygen species (ROS) levels and also its inhibitory effects on killing tumor cells by neutrophils isolated from clinical malignant pleural effusion (MPE) samples
• as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor to confirm the variation in inflammation was secondary to overproduction of reactive oxygen species (ROS) in cells treated with doxorubicin (DOX) + flagellin (FL)
• as an NADPH oxidase (NOX) inhibitor to study its effects on palmitate (PA)-induced sphere-forming ability of HepG2 (hepatocellular carcinoma) cells

Ações bioquímicas/fisiológicas

A potent and reversible inhibitor of nitric oxide synthetase from macrophages and endothelial cells. Also inhibits other flavoenzymes such as neutrophil NADPH oxidase.

Diphenyleneiodonium (DPI) can affect mitochondrial function. DPI can block neuron degeneration in Parkinson′s disease. It provides neuroprotection following focal cerebral ischemia. DPI can induce a chemo-quiescence phenotype in cancer stem-like cells, effectively inhibiting their proliferation.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)