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Documentos Principais

A7469

Sigma-Aldrich

L-Alanine

98.5-101.0%, suitable for cell culture, BioXtra, non-animal source

Sinônimo(s):

(S)-2-Aminopropionic acid, L-α-Aminopropionic acid

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About This Item

Fórmula empírica (Notação de Hill):
C3H7NO2
Número CAS:
Peso molecular:
89.09
Beilstein:
1720248
Número CE:
Número MDL:
Código UNSPSC:
12352209
eCl@ss:
32160406
ID de substância PubChem:
NACRES:
NA.26

product name

L-Alanine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

fonte biológica

non-animal source

Nível de qualidade

Agency

meets EP testing specifications
meets USP testing specifications

linha de produto

BioXtra

Ensaio

98.5-101.0%

forma

powder

técnica(s)

cell culture | mammalian: suitable

Impurezas

endotoxin, tested

cor

white

solubilidade

H2O: 100 mg/mL

aplicação(ões)

peptide synthesis
pharmaceutical (small molecule)

cadeia de caracteres SMILES

C[C@H](N)C(O)=O

InChI

1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1

chave InChI

QNAYBMKLOCPYGJ-REOHCLBHSA-N

Informações sobre genes

human ... CA1(759) , CA2(760)

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Aplicação

L-Alanine has been used for tissue culture technique as a media component. It has been used as a media component for the growth of adult mouse keratinocytes.

Ações bioquímicas/fisiológicas

L-Alanine is a nonessential amino acid, which is highly concentrated in muscle. It is a key player in the Glucose-Alanine cycle, which enables the removal of pyruvate and glutamate from muscle to the liver. Once in the liver, glucose is regenerated from pyruvate and returned to the muscle while glutamate ultimately participates in the urea cycle to form urea. The Glucose-Alanine cycle aides to conserve ATP in muscle for muscle contraction, while the energy burden of gluconeogenesis is imposed upon the liver. Alanine inhibits pyruvate kinase to regulate gluconeogenesis and glycolysis in order to maintain glucose homeostasis during starvation. Alanine prevents hepatic autophagy. Alanine formation is a result of transamination of glutamate and pyruvate.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Serial Cultivation of Primary Adult Murine Keratinocytes
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Methods in Molecular Biology, 15-22 (2005)
Alanine and Glutamine Synthesis and Release from Skeletal
Muscle
ALAN J. GARBER
The Journal of Biological Chemistry, 251(3) (1976)
A primary culture technique of adult retina for regeneration studies on adult CNS neurons
Alexandra Kretz
Nature Protocols, 131-140 (2007)
Muscle alanine synthesis and hepatic gluconeogenesis
Snell K
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Artigos

Sigma-Aldrich presents an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative phosphorylation, many tumor cells exhibit increased mitochondrial activity.

Chromatograms

application for HPLC

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