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A5835

Sigma-Aldrich

γ-Aminobutyric acid

≥99%, suitable for ligand binding assays, BioXtra

Sinônimo(s):

3-Carboxypropylamine, 4-Aminobutanoic acid, GABA, Piperidic acid, Piperidinic acid

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About This Item

Fórmula linear:
NH2(CH2)3COOH
Número CAS:
56-12-2
Peso molecular:
103.12
Beilstein:
906818
Número CE:
200-258-6
Número MDL:
MFCD00008226
Código UNSPSC:
12352106
ID de substância PubChem:
24891025
NACRES:
NA.26

Nome do produto

γ-Aminobutyric acid, BioXtra, ≥99%

linha de produto

BioXtra

Nível de qualidade

200

Ensaio

≥99%

Formulário

powder

técnica(s)

ligand binding assay: suitable

Impurezas

<0.0005% Phosphorus (P)
<0.1% Insoluble matter

resíduo de ignição

<0.1%

cor

white

pf

195 °C (dec.) (lit.)

solubilidade

H2O: 0.5 M at 20 °C, clear, colorless

traços de ânion

chloride (Cl-): <0.04%
sulfate (SO42-): <0.05%

traços de cátion

Al: <5 mg/kg
Ca: <20 mg/kg
Cu: <5 mg/kg
Fe: <5 mg/kg
K: <50 mg/kg
Mg: <50 mg/kg
NH4+: <500 mg/kg
Na: <70 mg/kg
Pb: <10 mg/kg
Zn: <5 mg/kg

cadeia de caracteres SMILES

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

chave InChI

BTCSSZJGUNDROE-UHFFFAOYSA-N

Informações sobre genes

human ... SLC6A1(6529) , SLC6A11(6538) , SLC6A12(6539)
rat ... Gabra1(29705) , Gabra2(29706) , Olr1750(294204) , Slc6a1(79212) , Slc6a12(50676)

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Categorias relacionadas

Descrição geral

γ-Aminobutyric acid (GABA) is a non-protein amino acid associated with the brain. Being synthesized in the nervous system, it is packed into synaptic vesicles. It is present naturally in green tea, soybean, germinated rice, and in some fermented foods.

Aplicação

γ-Aminobutyric acid (GABA) has been used to treat dorsal root ganglion neurons for electrophysiological recordings studies to test its effect on neuropathic pain in rats. It has also been used to test its protective effects in an ex vivo machine perfusion system of small-for-size grafts (SFSG) injury model.

Ações bioquímicas/fisiológicas

γ-Aminobutyric acid (GABA) is a mammalian inhibitory neurotransmitter with multiple functions. It is crucial for the normal central nervous system (CNS) functioning. A few documented functions of GABA include its protective role in toxin-induced damage. It also elicits anti-hypertensive, anti-diabetic, anti-microbial, antioxidant, anti-allergy, anti-inflammatory, and anti-cancer effects. GABA might show beneficial effects on stress and sleep in humans. γ-Aminobutyric acid (GABA) is used to study the biological and biochemical processes mediated via the GABA receptors, GABAA and GABAB.
Major inhibitory neurotransmitter in brain; GABAA and GABAB receptor agonist; increases Cl− conductance.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
BCCD3795
BCBT6042
BCBZ1867
BCBT8658
BCBR3355V

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Piril Hepsomali et al.
Frontiers in neuroscience, 14, 923-923 (2020-10-13)
Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. GABA's stress-reducing, and sleep enhancing effects have been established. However, although several human clinical trials have been conducted, results regarding the role
Li-Jie Wang et al.
Experimental and therapeutic medicine, 14(2), 1373-1380 (2017-08-16)
Niflumic acid (NFA) is a type of non-steroidal anti-inflammatory drug. Neuropathic pain is caused by a decrease in presynaptic inhibition mediated by γ-aminobutyric acid (GABA). In the present study, a whole-cell patch-clamp technique and intracellular recording were used to assess
Weiqiao Zhao et al.
Nature communications, 10(1), 124-124 (2019-01-12)
Innate preference toward environmental conditions is crucial for animal survival. Although much is known about the neural processing of sensory information, how the aversive or attractive sensory stimulus is transformed through central brain neurons into avoidance or approaching behavior is
Claudio Giachino et al.
Development (Cambridge, England), 141(1), 83-90 (2013-11-29)
Adult neurogenesis is tightly regulated through the interaction of neural stem/progenitor cells (NSCs) with their niche. Neurotransmitters, including GABA activation of GABAA receptor ion channels, are important niche signals. We show that adult mouse hippocampal NSCs and their progeny express
Vincent Paille et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(22), 9353-9363 (2013-05-31)
The spike-timing-dependent plasticity (STDP), a synaptic learning rule for encoding learning and memory, relies on relative timing of neuronal activity on either side of the synapse. GABAergic signaling has been shown to control neuronal excitability and consequently the spike timing
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