A4941

Activin A human

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

• Número CE: 201-069-1
• Número MDL: MFCD02685750
• Código UNSPSC: 12352202
• NACRES: NA.32

Propriedades

• fonte biológica: human
• Nível de qualidade: 200
• recombinante: expressed in baculovirus infected insect cells
• Ensaio: ≥95% (SDS-PAGE)
• forma: lyophilized powder
• potência: 1-10 ng/mL ED₅₀
• peso molecular: dimer 26 kDa (containing 116 amino acid residues βA subunits)
• embalagem: pkg of 10 μg; pkg of 5 μg
• técnica(s): cell culture | mammalian: suitable
• Impurezas: endotoxin, tested
• nº de adesão UniProt: P08476
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... INHBA(3624)

Descrição

Descrição geral

Activin A gene with two exons is mapped to human chromosome 2q35. Activin A also known as inhibin α-subunit belongs to the TGF-β (transforming growth factor-β) superfamily of proteins and its expression is exclusive to gonads, placenta and adrenal cortex.

Aplicação

Activin A human has been used as a constituent of modified barth′s saline used in in vitro induction of pronephros. It has also been used as a constituent of Roswell Park memorial institute (RPMI) media to induce pancreatic differentiation of multipotent dermal fibroblasts in vitro.

Ações bioquímicas/fisiológicas

Activins play a vital role in the regulation of hormonogenesis, cellular homeostasis and differentiation programs. Elevated expression of activin A and B leads to the loss of muscle mass. Both activin A and B have a potential to act as a serum markers of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

forma física

Lyophilized from 0.2 μm filtered solution in 10 mM sodium citrate, pH 3.0.

Nota de análise

The biological activity is determined by its ability to inhibit the proliferation of mouse MPC-11 cells.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H319 - H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable