H4666
Activin A human
recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
Sinônimo(s):
Activin A Protein, Growth Factor, Human Activin A
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About This Item
fonte biológica
human
Nível de qualidade
recombinante
expressed in HEK 293 cells
Ensaio
≥95% (SDS-PAGE)
forma
lyophilized powder
potência
≤5 ng/mL EC50
qualidade
endotoxin tested
peso molecular
dimer 25 kDa (non-glycosylated)
embalagem
pkg of 5x10 μg
pkg of 10 μg
técnica(s)
cell culture | mammalian: suitable
Impurezas
≤1 EU/mg
temperatura de armazenamento
−20°C
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Categorias relacionadas
Ações bioquímicas/fisiológicas
Activin-A participates in a diverse array of functions that include; hypothalamic/pituitary/gonadal hormone secretion, insulin secretion; cell growth, differentiation and survival (apoptosis); embryonic patterning and development; wound healing; and inflammation/immune response. It was initially identified as a follicle stimulating hormone/FSH-releasing protein (gonadal hormone), Ling N, et al. (1986) and erythroid differentiation factor (EDF), Schwall R, et al. (1989). The FSH activity is linked to an increase in the population of pituitary gonadotrophs by Katayama T, et al. (1990). In addition to gonadotrophs, activin-A also modifies somatotrophs and lactotrophs, Kitaoka, et al. (1988).
Activin-A stimulates glycogenolysis in isolated rat hepatocytes, Mine T ET. al. (1989) and elevates insulin release from rat pancreatic islets, Verspohl EJ et al. (1993). Activin-A stimulates insulin secretion in rat pancreatic islets, Totsuka Y, et al. (1988).
Follistatin, an activin-binding protein, is a principle regulator of activin activity, de Winter JP, et al. (1996); however during embryogenesis, Cripto is an important noncompetitive activin antagonist that facilitates Nodal signaling, Kelber JA, et al. (2008).
A role for activin-A as a regulator of cell proliferation was recognized by Gonzalez-Manchon C and Vale W. (1989); wherein Act-A inhibited the growth of and induced morphological changes in CHO-KI cells in culture, in a way similar to but less potent than TGF-β.
Activin A is involved with the entire process of embryo development from germ cells thru embryonic development to adult tissues. It stimulates spermatogonial proliferation in germ-Sertoli cell cocultures, Mather JP, et al. (1990) and is a maturation factor for oocytes, Itoh M, et al. (1990). Activin A promotes proliferation of human luteinized preovulation granulose cells (ovarian granulose cells), Rabinovici J, et al. (1990).
Activin-A stimulates glycogenolysis in isolated rat hepatocytes, Mine T ET. al. (1989) and elevates insulin release from rat pancreatic islets, Verspohl EJ et al. (1993). Activin-A stimulates insulin secretion in rat pancreatic islets, Totsuka Y, et al. (1988).
Follistatin, an activin-binding protein, is a principle regulator of activin activity, de Winter JP, et al. (1996); however during embryogenesis, Cripto is an important noncompetitive activin antagonist that facilitates Nodal signaling, Kelber JA, et al. (2008).
A role for activin-A as a regulator of cell proliferation was recognized by Gonzalez-Manchon C and Vale W. (1989); wherein Act-A inhibited the growth of and induced morphological changes in CHO-KI cells in culture, in a way similar to but less potent than TGF-β.
Activin A is involved with the entire process of embryo development from germ cells thru embryonic development to adult tissues. It stimulates spermatogonial proliferation in germ-Sertoli cell cocultures, Mather JP, et al. (1990) and is a maturation factor for oocytes, Itoh M, et al. (1990). Activin A promotes proliferation of human luteinized preovulation granulose cells (ovarian granulose cells), Rabinovici J, et al. (1990).
Nota de análise
The specific activity was determined by the dose-dependent inhibition of proliferation of the MPC-11 cell line (mouse plasmocytoma cell line).
Informações legais
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Yan Li et al.
The Journal of clinical endocrinology and metabolism, 100(11), E1415-E1427 (2015-08-26)
Activin A increases matrix metalloproteinase (MMP) 2 expression and cell invasion in human trophoblasts, but whether the expression of MMP2 is essential for the proinvasive effect of activin A has yet to be determined. Moreover, the identity of the activin
Hannah E J Yong et al.
Pregnancy hypertension, 5(4), 346-353 (2015-11-26)
Activin A, a TGFβ family member, circulates in the maternal blood at increasing concentrations throughout gestation during a healthy pregnancy. The circulating concentration of activin A is further increased in pre-eclampsia (PE), a hypertensive disorder of pregnancy that is marked
Xu Qian et al.
Biomaterials, 35(36), 9581-9590 (2014-09-06)
Well-defined culture conditions are essential for realizing the full potential of human embryonic stem cells (hESCs) in regenerative medicine where large numbers of cells are required. Synthetic polymers such as poly[2-(methacryloyloxy) ethyl dimethyl-(3-sulfopropyl) ammonium hydroxide] (PMEDSAH), offer multiple advantages over
Melissa L Brown et al.
Islets, 6(5-6), e1017226-e1017226 (2015-04-04)
Emerging evidence suggests that activin with its associated receptors, second messengers, and antagonists would be excellent targets for therapeutic drug development in the treatment of diabetes. We undertook the current study to investigate the ability to extrapolate findings from rodent
Yasuhide Ohinata et al.
PloS one, 9(9), e107308-e107308 (2014-09-10)
The inner cell mass (ICM) and trophoblast cell lineages duet early embryonic development in mammals. After implantation, the ICM forms the embryo proper as well as some extraembryonic tissues, whereas the trophoectoderm (TE) exclusively forms the fetal portion of the
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