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A0788

Sigma-Aldrich

3-Aminobenzamide

≥99% (TLC)

Sinônimo(s):

3-AB, 3-ABA

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About This Item

Fórmula linear:
H2NC6H4CONH2
Número CAS:
3544-24-9
Peso molecular:
136.15
Número CE:
222-586-9
Número MDL:
MFCD00007989
Código UNSPSC:
12352200
ID de substância PubChem:
24278206
NACRES:
NA.77

Ensaio

≥99% (TLC)

forma

powder

cor

white to off-white

pf

115-116 °C (lit.)

solubilidade

ethanol: 50 mg/mL, clear, light yellow
DMSO: soluble
H2O: soluble (may require gentle heating)

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

NC(=O)c1cccc(N)c1

InChI

1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)

chave InChI

GSCPDZHWVNUUFI-UHFFFAOYSA-N

Informações sobre genes

mouse ... Parp1(11545)

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Aplicação

3-Aminobenzamide has been used as a poly-(ADP-ribose) polymerase (PARP) inhibitor in various experimental studies.

Ações bioquímicas/fisiológicas

3-Aminobenzamide enhances cell death, unscheduled DNA synthesis and repair replication by interrupting the rejoining of DNA strand breaks induced by both ionizing radiations and several alkylating agents. It has an ability to inhibit the activity of nuclear enzyme poly (ADP-ribose) synthetase (PARS). 3-Aminobenzamide exhibits protective action against myocardial reperfusion injury and local inflammation.

Características e benefícios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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An improved nonisotopic test to screen a large series of new inhibitor molecules of poly (ADP-ribose) polymerase activity for therapeutic applications
Decker P, et al.
Clinical Cancer Research, 5(5), 1169-1172 (1999)
Poly (ADP-ribose) synthetase inhibition prevents lipopolysaccharide-induced peroxynitrite mediated damage in diaphragm
OzduLger A, et al.
Pharmacological Research, 46(1), 67-73 (2002)
Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase
Zingarelli B, et al.
Cardiovascular Research, 36(2), 205-215 (1997)
Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in a carrageenan-induced model of local inflammation
Cuzzocrea S, et al.
European Journal of Pharmacology, 342(1), 67-76 (1998)
M L Kuo et al.
Biochemical and biophysical research communications, 219(2), 502-508 (1996-02-15)
Previous studies have shown that chemically generated nitric oxide (NO) can induce human leukemia HL-60 cells to undergo monocytic differentiation. We show here that exposure of HL-60 cells to chemical NO generators induces cell death via apoptosis which was examined
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Conteúdo relacionado

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number of regulatory and effector molecules.

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