D5314
DPQ
≥98% (HPLC), solid
Sinônimo(s):
3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone
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About This Item
Fórmula empírica (Notação de Hill):
C18H26N2O2
Número CAS:
Peso molecular:
302.41
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.77
Produtos recomendados
fonte biológica
synthetic (organic)
Nível de qualidade
Ensaio
≥98% (HPLC)
Formulário
solid
pf
107-109 °C
solubilidade
DMSO: 1 mg/mL, clear, colorless to faintly yellow
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
N3(CCCCC3)CCCCOc1c2c(ccc1)C(=O)NCC2
InChI
1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
chave InChI
RVOUDNBEIXGHJY-UHFFFAOYSA-N
Aplicação
DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.
Ações bioquímicas/fisiológicas
3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.
DPQ is a very potent poly(ADP-ribose) polymerase (PARP) inhibitor.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
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Cell death induced by excessive glutamate receptor overactivation, excitotoxicity, has been implicated in several acute and chronic neurological disorders. While numerous studies have demonstrated the contribution of biochemically and genetically activated cell death pathways in excitotoxic injury, the factors mediating
M J Suto et al.
Anti-cancer drug design, 6(2), 107-117 (1991-05-01)
A series of dihydroisoquinolinones, formally rigid analogs of 3-substituted benzamides, and a series of 2,3-disubstituted benzamides were synthesized and evaluated as inhibitors of poly(ADP-ribose) polymerase. The results indicated that the orientation of the amide with respect to the substituent on
Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses, 29-29 (2012)
M J Eliasson et al.
Nature medicine, 3(10), 1089-1095 (1997-10-23)
Nitric oxide (NO) and peroxynitrite, formed from NO and superoxide anion, have been implicated as mediators of neuronal damage following focal ischemia, but their molecular targets have not been defined. One candidate pathway is DNA damage leading to activation of
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