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Documentos Principais

A0310

Sigma-Aldrich

Monoclonal Anti-GABA antibody produced in mouse

clone GB-69, ascites fluid

Sinônimo(s):

GABA Antibody - Monoclonal Anti-GABA antibody produced in mouse, Gaba Antibody Sigma, Anti-γ-Aminobutyric acid

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

conjugado

unconjugated

forma do anticorpo

ascites fluid

tipo de produto de anticorpo

primary antibodies

clone

GB-69, monoclonal

contém

15 mM sodium azide

reatividade de espécies

wide range

técnica(s)

dot blot: suitable
immunofluorescence: suitable
immunohistochemistry: 1:100-1:200 (Using heat-retrieved formalin-fixed, paraffin-embedded human brain and/or cerebellum sections.)
indirect ELISA: suitable

Isotipo

IgG1

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

mouse ... Gabra1(14394)

Descrição geral

γ-Aminobutyric acid (GABA) functions as an inhibitory neurotransmitter in the central nervous system. It also functions as a neuromodulator in some peripheral tissues. Additionally, GABA is present in non-nervous tissues and regulates blood pressure, heart rate, respiration, immunomodulation, cell proliferation, protein synthesis and metabolism.
Monoclonal Anti-GABA (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. The antibody does not cross react with L-α-aminobutyric acid, L-glutamic acid, L-aspartic acid, glycine, δ-aminovaleric acid, L-threonine, L-glutamine, taurine, putrescine, L-alanine and carnosine. However, weak cross-reaction is observed with β-alanine and ε-aminocaproic acid.
Monoclonal Anti-GABA (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system and a neuromodulator in certain peripheral tissues. GABA is also present in non-nervous structures.

Imunogênio

GABA (γ-aminobutyric acid) conjugated to BSA

Aplicação

Monoclonal Anti-GABA antibody produced in mouse has been used in immunohistochemistry and immunocytochemistry.

Ações bioquímicas/fisiológicas

γ-Aminobutyric acid (GABA) mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

forma física

Supplied as ascites fluid with 15 mM sodium azide as preservative.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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The Journal of comparative neurology, 516(4), 291-311 (2009-07-28)
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Edqvist PHD and Hallbook F
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Aaron N Reifler et al.
Current biology : CB, 25(21), 2763-2773 (2015-10-07)
Retinal neurons exhibit sustained versus transient light responses, which are thought to encode low- and high-frequency stimuli, respectively. This dichotomy has been recognized since the earliest intracellular recordings from the 1960s, but the underlying mechanisms are not yet fully understood.
GABA may be a neurotransmitter in the vertebrate peripheral nervous system
Jessen KR, et al.
Nature, 281(5726), 71-71 (1979)

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