95271

Vitamin K₁

BioXtra, ≥99.0% (sum of isomers, HPLC), mixture of isomers

• Sinônimo(s): 2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, Vitamin K₁₍₂₀₎
• Fórmula empírica (Notação de Hill): C₃₁H₄₆O₂
• Número CAS: 84-80-0
• Peso molecular: 450.70
• Beilstein: 2568816
• Número CE: 201-564-2
• Número MDL: MFCD00214063
• Código UNSPSC: 12352205
• ID de substância PubChem: 57653664
• NACRES: NA.79

Propriedades

• fonte biológica: synthetic
• linha de produto: BioXtra
• Ensaio: ≥99.0% (sum of isomers, HPLC)
• forma: viscous liquid
• Impurezas: ≤20% cis-isomer
• resíduo de ignição: ≤0.1% (as SO₄)
• cor: light green-yellow to dark green-yellow; light yellow to dark yellow
• índice de refração: n20/D 1.527 (lit.)
• pf: −20 °C (lit.)
• densidade: 0.984 g/mL at 25 °C (lit.)
• traços de cátion: Al: ≤5 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤100 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤10 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C(C1=CC=CC=C21)C(C)=C(C/C=C(CCC[C@@H](CCC[C@H](C)CCCC(C)C)C)\C)C2=O
• InChI: 1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
• chave InChI: MBWXNTAXLNYFJB-NKFFZRIASA-N

Descrição

Descrição geral

Vitamin K₁, also known as phylloquinone, consists of naphthalenoid and phytyl groups. Phylloquinone is present abundantly in photosynthetic plants and is a major dietary source. It is a fat-soluble vitamin.

Aplicação

<ul>
<li><strong>Nutritional strategies for musculoskeletal health:</strong> Nutritional strategies, including Vitamin K1, optimize musculoskeletal health for fall and fracture prevention beyond traditional nutrients like calcium and vitamin D (Webster et al., 2023 doi:10.1016/j.bonr.2023.101684).</li>
<li><strong>Role in coagulation and bone health:</strong> A comprehensive review highlights Vitamin K1′s role in reducing cardiovascular risks and details its biochemical interactions affecting coagulation and bone health (Zhao et al., 2024 doi:10.1017/jns.2023.106).</li>
</ul>

Ações bioquímicas/fisiológicas

Vitamin K1 (Phylloquinone) is a lipid soluble polycyclic aromatic ketone used as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX and X; anticoagulant factors protein C and S and as a cell signaling factor.

Vitamin K₁ plays a role as a cofactor in the synthesis of γ- carboxy glutamate (Gla), formation of coagulation factors II (prothrombin), VII, IX and X.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Outras notas

Review: Vitamin K and γ-carboxyglutamate biosynthesis; Metabolic functions and mechanism of action

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves