Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos Principais

Visualizar Toda a Documentação

90182

Sigma-Aldrich

Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride

≥99.0% (AT)

Sinônimo(s):

(3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride, (3S)-7-Amino-1-chloro-3-tosylamino-2-heptanone hydrochloride, TLCK, Tosyl-L-lysyl-chloromethane hydrochloride

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C14H21ClN2O3S · HCl
Número CAS:
4272-74-6
Peso molecular:
369.31
Beilstein:
7106867
Número CE:
224-266-4
Número MDL:
MFCD00065395
Código UNSPSC:
12352202
eCl@ss:
32160406
ID de substância PubChem:
57653369
NACRES:
NA.77

fonte biológica

synthetic

Nível de qualidade

100

Ensaio

≥99.0% (AT)

forma

powder or crystals

atividade óptica

[α]20/D −7.8±0.5°, c = 2% in H2O

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

Cl[H].Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl

InChI

1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1

chave InChI

YFCUZWYIPBUQBD-ZOWNYOTGSA-N

Procurando produtos similares? Visita Guia de comparação de produtos

Outras notas

An alkylating reagent that may react with histidine or cysteine residues at the active site of enzymes. Inactivates serine proteases such as trypsin and clostripain . Chymotrypsin is not affected. To prevent proteolytic degradation, a combination of TLCK and TPCK can be used throughout the isolation of proteins, as in the isolation of histones.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 1

1 of 1

Pepstatina A microbial, ≥90% (HPLC)

Sigma-Aldrich

P5318

Pepstatina A

Further observations on substrate-derived chloromethyl ketones that inactivate trypsin.
E Shaw et al.
Archives of biochemistry and biophysics, 139(2), 298-305 (1970-08-01)
J M Griscavage et al.
Biochemical and biophysical research communications, 215(2), 721-729 (1995-10-13)
The objective of this study was to ascertain the mechanism by which serine and cysteine proteinase inhibitors interfere with production of NO by LPS-activated rat alveolar macrophages. Macrophages were incubated in the presence of LPS+ test agent for 24 hr.
Studies on the active site of clostripain. The specific inactivation by the chloromethyl ketone derived from -N-tosyl-L-lysine.
W H Porter et al.
The Journal of biological chemistry, 246(24), 7675-7682 (1971-12-25)
M K Urban et al.
Biochemistry, 18(18), 3952-3960 (1979-09-04)
Chicken erythrocyte histones 2A, 2B, and 3 can be resolved into nonallelic primary structure variants by polyacrylamide gel electrophoresis in the presence of Triton X-100. These variants were isolated and characterized by analysis of their tryptic and thermolytic peptides. The
I Kourteva et al.
Analytical biochemistry, 162(2), 345-349 (1987-05-01)
A technique for quickly detecting nanogram quantities of low- and high-molecular-weight inhibitors of some serine proteases is described. The inhibitor solutions are spotted onto agar films which contain either L-1-p-tosylamino-2-phenylethyl chloromethyl ketone (TPCK)-trypsin or tosyl lysine chloromethyl ketone (TLCK)-chymotrypsin. Enzyme
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica