14370
Bilirrubina
purum, ≥95.0% (UV)
Sinônimo(s):
Bile pigment, Hemetoidin
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About This Item
Fórmula empírica (Notação de Hill):
C33H36N4O6
Número CAS:
Peso molecular:
584.66
Beilstein:
74376
Número CE:
Número MDL:
Código UNSPSC:
12352202
ID de substância PubChem:
NACRES:
NA.25
Produtos recomendados
grau
purum
Nível de qualidade
Ensaio
≥95.0% (UV)
Formulário
powder
resíduo de ignição
≤0.5%
cadeia de caracteres SMILES
CC1=C(C=C)\C(NC1=O)=C\c2[nH]c(Cc3[nH]c(\C=C4/NC(=O)C(C=C)=C4C)c(C)c3CCC(O)=O)c(CCC(O)=O)c2C
InChI
1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
chave InChI
BPYKTIZUTYGOLE-IFADSCNNSA-N
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Descrição geral
Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase.
Aplicação
Bilirubin has been used as an interfering substance for in vitro interference and stability tests for myoglobin, creatine kinase-MB (CK-MB), and troponin-I. It has also been used as an interfering agent to test the effectiveness of the Heparin Red kit in the detection of various heparins.
Ações bioquímicas/fisiológicas
Muito mais de 99% da bilirrubina total são transportados conjugados com albumina. Níveis anormalmente alto de bilirrubina podem causar graves danos neurológicos, mas níveis ligeiramente elevados estão associados à proteção contra o estresse oxidativo.
Bilirubin is an active oxidative DNA cleaving agent as well as an effective antioxidant agent, a hydroxyl radical quencher. This bile pigment has both antioxidant and toxic properties. It is a natural inhibitor of vascular smooth muscle cell proliferation (VSMCs). It displays anti-inflammatory and anti-proliferative properties when used as a therapeutic agent in lung/vascular diseases. Serum bilirubin concentration slightly above the normal levels have shown a lesser incidence of heart disease. It is a potential therapeutic agent in heart transplantation and T-cell mediated immune disorders.
Nota de análise
λmax. ∼453 nm, mol. absorption >56100 (chloroform)
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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There is no histologic classification system to determine prognoses of patients with alcoholic hepatitis (AH). We identified histologic features associated with disease severity and created a histologic scoring system to predict short-term (90-day) mortality. We analyzed data from 121 patients
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