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Y0001404

Vigabatrin impurity D

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

γ-Aminobutyric acid, 3-Carboxypropylamine, 4-Aminobutanoic acid, GABA, Piperidic acid, Piperidinic acid

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About This Item

Fórmula linear:
NH2(CH2)3COOH
Número CAS:
56-12-2
Peso molecular:
103.12
Beilstein:
906818
Número MDL:
MFCD00008226
Código UNSPSC:
41116107
ID de substância PubChem:
329831405
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

vigabatrin

fabricante/nome comercial

EDQM

pf

195 °C (dec.) (lit.)

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

chave InChI

BTCSSZJGUNDROE-UHFFFAOYSA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Vigabatrin impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Ações bioquímicas/fisiológicas

Major inhibitory neurotransmitter in brain; GABAA and GABAB receptor agonist; increases Cl− conductance.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Lot/Batch Number

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Hussein A N Al-Wadei et al.
Molecular nutrition & food research, 55(12), 1745-1758 (2011-08-02)
GABA is a bioactive constituent of fruits, vegetables, cereals and is believed to play a role in defense against stress in plants. In animals, it acts as an inhibitory neurotransmitter in brain while also expressed in non-neuronal cells. Studies have
Jesse Jackson et al.
Nature neuroscience, 17(10), 1362-1370 (2014-09-01)
Activity flow through the hippocampus is thought to arise exclusively from unidirectional excitatory synaptic signaling from CA3 to CA1 to the subiculum. Theta rhythms are important for hippocampal synchronization during episodic memory processing; thus, it is assumed that theta rhythms
Shang-Feng Gao et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 17(1), 124-144 (2010-03-20)
Stress response and depression have a significant impact on modern society. Although the symptoms are well characterized, the molecular mechanisms underlying depression are largely unknown. The monoamine hypothesis, which postulates dysfunctional noradrenergic and serotonergic systems as the underlying primary cause
W-Y Lu et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 39(7), 956-961 (2009-04-30)
Asthma often occurs as a result of immune-based inflammatory responses, which consequently cause pathological changes in airway structural cells. However, the underlying mechanisms of airway pathology in asthma are still not fully understood. Our recent studies revealed a critical role
T Clayton et al.
Current medicinal chemistry, 14(26), 2755-2775 (2007-11-30)
A successful unified pharmacophore/receptor model which has guided the synthesis of subtype selective compounds is reviewed in light of recent developments both in ligand synthesis and structural studies of the binding site itself. The evaluation of experimental data in combination
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