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Y0000366

Isradipine

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

4-(4-Benzofurazanyl)-1,-4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester

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About This Item

Fórmula empírica (Notação de Hill):
C19H21N3O5
Número CAS:
75695-93-1
Peso molecular:
371.39
Número MDL:
MFCD00153820
Código UNSPSC:
41116107
ID de substância PubChem:
329830922
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

isradipine

fabricante/nome comercial

EDQM

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

COC(=O)C1=C(C)NC(C)=C(C1c2cccc3nonc23)C(=O)OC(C)C

InChI

1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3

chave InChI

HMJIYCCIJYRONP-UHFFFAOYSA-N

Informações sobre genes

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Isradipine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Ações bioquímicas/fisiológicas

L-type calcium channel blocker (also referred to as dihydropyridine-type calcium channel blocker); antihypertensive.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Lot/Batch Number

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R O Feneck et al.
Acta anaesthesiologica Scandinavica. Supplementum, 99, 38-42 (1993-01-01)
Isradipine has been shown to be an effective vasodilator in different vascular beds. Experimental evidence suggests that isradipine is a potent coronary vasodilator, and this is supported by clinical studies in both cardiology and cardiac surgery. Furthermore, in these studies
M Schachter
Journal of clinical pharmacy and therapeutics, 16(2), 79-91 (1991-04-01)
Isradipine is a potent dihydropyridine calcium channel blocker. It is highly selective for vascular smooth muscle, with very few negative inotropic or chronotropic effects. It may have minor depressant effects on the sinoatrial node, hence reducing the incidence of reflex
F Bernini et al.
American journal of hypertension, 7(7 Pt 2), 30S-34S (1994-07-01)
A number of studies in experimental animal models have demonstrated the potential direct antiatherosclerotic effects of calcium antagonists. This class of compounds can influence several processes that are involved in the development of atherosclerotic lesions. This action is independent of
J B Leslie
Acta anaesthesiologica Scandinavica. Supplementum, 99, 33-37 (1993-01-01)
The significant effects of isradipine in producing arterial vasodilation and mild negative chronotropic effects without significant negative inotropic effects suggests that this agent should provide excellent antihypertensive efficacy in the treatment of perioperative hypertension. Isradipine may prove to be a
D Panuccio et al.
La Clinica terapeutica, 146(11), 729-736 (1995-11-01)
The aim of the present study was to evaluate efficacy on blood pressure values and metabolic tolerability of Isradipine, which was given to 15 mild hypertensive non diabetic subjects (average age 63.8 +/- 10.9 years), at the dosage of 5
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