PHR1587

Timerosal

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinônimo(s): Etilmercuritiossalicilato de sódio, Mercúrio-([o-carboxifenil]tio)etil, Ácido 2-(etilmercuriomercapto)benzoico, Ácido etilmercuritiossalicílico
• Fórmula linear: 2-(C₂H₅HgS)C₆H₄CO₂Na
• Número CAS: 54-64-8
• Peso molecular: 404.81
• Beilstein: 8169555
• Número CE: 200-210-4
• Número MDL: MFCD00013062
• Código UNSPSC: 41116107
• ID de substância PubChem: 329823493
• NACRES: NA.24

Propriedades

• grau: certified reference material; pharmaceutical secondary standard
• Nível de qualidade: 300
• Agency: traceable to Ph. Eur. Y0000109; traceable to USP 1659000
• família API: thimerosal
• Certificado de análise (CofA): current certificate can be downloaded
• embalagem: pkg of 1 g
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• pf: 234-237 °C (dec.) (lit.)
• aplicação(ões): pharmaceutical (small molecule)
• Formato: neat
• temperatura de armazenamento: 2-30°C
• cadeia de caracteres SMILES: [Na+].CC[Hg]Sc1ccccc1C([O-])=O
• InChI: 1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2
• chave InChI: RTKIYNMVFMVABJ-UHFFFAOYSA-L

Descrição

Descrição geral

Thimerosal belongs to the group of alkyl mercury compounds. Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Aplicação

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Thimerosal may be used as a pharmaceutical reference standard for the quantification of the analyte in ophthalmic solutions using spectrophotometric technique.

Ações bioquímicas/fisiológicas

O timerosal é um reagente oxidante de sulfidrila (tiol) capaz de inibir uma ampla gama de enzimas e proteínas dependentes de sulfidrila, como a metionina sintase dependente de PI3-quinase, receptores de transporte de glutamato e ATPases dependentes de Na⁺+K⁺.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAA6959 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Exoneração de responsabilidade

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

Informações de segurança

• Pictogramas: GHS06,GHS08,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H300 + H310 + H330,H373,H410
• Declarações de precaução: P262 - P264 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Classificações de perigo: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral
• Órgãos-alvo: Kidney
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable