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Y0000109

Timerosal

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

Etilmercuritiossalicilato de sódio, Mercúrio-([o-carboxifenil]tio)etil, Ácido 2-(etilmercuriomercapto)benzoico, Ácido etilmercuritiossalicílico

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About This Item

Fórmula linear:
2-(C2H5HgS)C6H4CO2Na
Número CAS:
54-64-8
Peso molecular:
404.81
Beilstein:
8169555
Número MDL:
MFCD00013062
Código UNSPSC:
41116107
ID de substância PubChem:
329830849
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

thimerosal

fabricante/nome comercial

EDQM

pf

234-237 °C (dec.) (lit.)

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[Na+].CC[Hg]Sc1ccccc1C([O-])=O

InChI

1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2

chave InChI

RTKIYNMVFMVABJ-UHFFFAOYSA-L

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Thimerosal EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Ações bioquímicas/fisiológicas

O timerosal é um reagente oxidante de sulfidrila (tiol) capaz de inibir uma ampla gama de enzimas e proteínas dependentes de sulfidrila, como a metionina sintase dependente de PI3-quinase, receptores de transporte de glutamato e ATPases dependentes de Na++K+.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Exoneração de responsabilidade

As part of the corporation global plan to support the Minamata Convention in eliminating mercury-containing compounds, as of January 2021 customers will be required to provide an End-Use Declaration. The sales of thimerosal will be restricted for approved applications only, such as preservative in vaccine manufacturing, preservative in eye cosmetics, research use within academia (excluding preservation intent) and as reference material only.

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act , European Biocidal Products Regulation, Canada′s Pest Management Regulatory Agency, Turkey′s Biocidal Products Regulation, Korea′s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral

Órgãos-alvo

Kidney

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Global justice and the proposed ban on thimerosal-containing vaccines.
Katherine King et al.
Pediatrics, 131(1), 154-156 (2012-12-19)
Janet K Kern et al.
International journal of environmental research and public health, 10(8), 3771-3800 (2013-08-24)
Autism spectrum disorder (ASD) is a neurological disorder in which a significant number of the children experience a developmental regression characterized by a loss of previously acquired skills and abilities. Typically reported are losses of verbal, nonverbal, and social abilities.
José G Dórea
Clinica chimica acta; international journal of clinical chemistry, 411(21-22), 1580-1586 (2010-07-20)
To compare epidemiological studies dealing with neurological issues (compatible with Hg toxicity) linked to exposing newborns and infants to intramuscular doses of preservative-Hg resulting from vaccination with thimerosal-containing vaccines (TCV). Major databases were searched for studies that addressed neurodevelopment outcomes
L K Ball et al.
Pediatrics, 107(5), 1147-1154 (2001-05-23)
On July 7, 1999, the American Academy of Pediatrics and the US Public Health Service issued a joint statement calling for removal of thimerosal, a mercury-containing preservative, from vaccines. This action was prompted in part by a risk assessment from
José G Dórea
Neurochemical research, 36(6), 927-938 (2011-02-26)
There is a need to interpret neurotoxic studies to help deal with uncertainties surrounding pregnant mothers, newborns and young children who must receive repeated doses of Thimerosal-containing vaccines (TCVs). This review integrates information derived from emerging experimental studies (in vitro
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