H5501

Metil 4-hidroxibenzoato

ReagentPlus^®, ≥99.0%, crystalline

• Sinônimo(s): Éster metílico de ácido p-hidroxibenzoico, Metilparabeno, NIPAGIN
• Fórmula linear: HOC₆H₄CO₂CH₃
• Número CAS: 99-76-3
• Peso molecular: 152.15
• Beilstein: 509801
• Número CE: 202-785-7
• Número MDL: MFCD00002352
• Código UNSPSC: 51452201
• ID de substância PubChem: 329815219
• NACRES: NA.25

Propriedades

• Nível de qualidade: 200
• linha de produto: ReagentPlus^®
• Ensaio: ≥99.0%
• Formulário: crystalline
• pf: 125-128 °C (lit.)
• cadeia de caracteres SMILES: COC(=O)c1ccc(O)cc1
• InChI: 1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3
• chave InChI: LXCFILQKKLGQFO-UHFFFAOYSA-N

Descrição

Aplicação

Methyl 4-hydroxybenzoate has been used:

• in sex-linked recessive lethal (SLRL) test in Drosophila melanogaster
• as a constituent in cream formulation
• as an antifungal agent in Drosophila melanogaster culture

Ações bioquímicas/fisiológicas

Methyl 4-hydroxybenzoate, also called methyl paraben or nipagin, comprises the ester of p-hydroxybenzoic acid. It is present naturally in cloudberry, white wine and bourbon vanilla. Methyl 4-hydroxybenzoate has antimicrobial and antifungal functionality and is commercially used as a preservative in the food, cosmetic and pharmaceutical industry. Methyl 4-hydroxybenzoate has cytotoxic effects on keratinocytes in the presence of sunlight. Methyl 4-hydroxybenzoate upon solar irradiation mediates DNA damage and modulates esterase metabolism resulting in skin damage and favors cancer progression. Methyl 4-hydroxybenzoate has estrogenic functionality and upregulates estrogen-related genes.

Informações legais

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

Informações de segurança

• Pictogramas: GHS09
• Frases de perigo: H411
• Declarações de precaução: P273 - P391 - P501
• Classificações de perigo: Aquatic Chronic 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): 334.4 °F
• Ponto de fulgor (°C): 168 °C
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves