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B3916

Supelco

Boldine

analytical standard

Sinônimo(s):

2,9-Dihydroxy-1,10-dimethoxyaporphine

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About This Item

Fórmula empírica (Notação de Hill):
C19H21NO4
Número CAS:
476-70-0
Peso molecular:
327.37
Beilstein:
94036
Número CE:
207-509-9
Número MDL:
MFCD00135040
Código UNSPSC:
41116107
ID de substância PubChem:
329773223
NACRES:
NA.24

fonte biológica

plant (Peumus boldus molina)

Nível de qualidade

100

grau

analytical standard

Ensaio

≥98% (TLC)

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

Impurezas

≤1% isopropanol

pf

157-164  °C

solubilidade

ethanol: 50 mg/mL

aplicação(ões)

food and beverages
forensics and toxicology
veterinary

Formato

neat

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

COc1cc-2c(CC3N(C)CCc4cc(O)c(OC)c-2c34)cc1O

InChI

1S/C19H21NO4/c1-20-5-4-10-7-15(22)19(24-3)18-12-9-16(23-2)14(21)8-11(12)6-13(20)17(10)18/h7-9,13,21-22H,4-6H2,1-3H3/t13-/m0/s1

chave InChI

LZJRNLRASBVRRX-ZDUSSCGKSA-N

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Descrição geral

Boldine is an aporphine alkaloid isolated from Boldo tree and other plant species. It is a free radical scavenger with anti-inflammatory activity while exhibiting other pharmacological effects such as antidiabetic, antiplatelet aggregation, antipyretic, antinociceptive, antiatherogenic, hepatoprotective and endothelium-protective activity.

Aplicação

Boldine may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical preparations using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H315,H319,H335

Classificações de perigo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
BCBX5558
SLBB0164V

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Franz A Thomet et al.
Molecules (Basel, Switzerland), 16(3), 2253-2258 (2011-03-09)
2,9-Dimethoxymethylboldine (2), 2,9-dimethoxymethyl-3-bromoboldine (3) and 2,9-dimethoxymethyl-3-diphenylphosphinylboldine (4) have been synthesized in an effort to find compounds with potential pharmacological applications. The cytotoxic activities of the natural precursor 1 and these three derivatives have been measured as IC₅₀ inhibitory growth. The
Yeh Siang Lau et al.
Biochemical pharmacology, 85(3), 367-375 (2012-11-28)
Increased oxidative stress is involved in the pathogenesis and progression of diabetes. Antioxidants are therapeutically beneficial for oxidative stress-associated diseases. Boldine ([s]-2,9-dihydroxy-1,10-dimethoxyaporphine) is a major alkaloid present in the leaves and bark of the boldo tree (Peumus boldus Molina), with
Qi-Zhi Zhao et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 40(10), 931-934 (2006-01-18)
To study the alkaloid constituents of the root of Lindera angustifolia Cheng. The constituents were isolated and purified by column chromatography and the structures were characterized by spectral analysis. Seven aporphine alkaloids, laurotetanine (I), N-methyllaurotetanine (II), boldine (III), isoboldine (IV)
Lip Yong Chung et al.
Phytotherapy research : PTR, 23(3), 330-334 (2008-10-11)
A 96-well microplate filtration based 5-HT(2A) receptor-radioligand binding assay was optimized and adopted to carry out a bioassay-guided fractionation of the methanol extract of the leaves of Litsea sessilis. This purification led to the isolation of two compounds identified as
Bangning Yu et al.
Journal of medicinal food, 12(5), 1074-1083 (2009-10-28)
Adiponectin is an adipokine secreted by differentiated adipocytes. Clinical studies suggest a negative correlation between oxidative stress and adiponectin levels in patients with metabolic syndrome or cardiovascular disease. Natural compounds that can prevent oxidative stress mediated inhibition of adiponectin may
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