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55513

Supelco

Spermine

analytical standard

Sinônimo(s):

N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine

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About This Item

Fórmula linear:
NH2(CH2)3NH(CH2)4NH(CH2)3NH2
Número CAS:
71-44-3
Peso molecular:
202.34
Beilstein:
1750791
Número CE:
200-754-2
Número MDL:
MFCD00008215
Código UNSPSC:
85151701
ID de substância PubChem:
329758127
NACRES:
NA.24

grau

analytical standard

Nível de qualidade

100

Ensaio

≥99.0% (GC)
97.0-103.0% (T)

prazo de validade

limited shelf life, expiry date on the label

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

Impurezas

≤0.5% carbonate
≤0.5% spermidine

pb

150 °C/5 mmHg (lit.)

pf

28-30 (lit.)

aplicação(ões)

cleaning products
cosmetics
food and beverages
personal care

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[H]N(CCCN)CCCCN([H])CCCN

InChI

1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2

chave InChI

PFNFFQXMRSDOHW-UHFFFAOYSA-N

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Aplicação

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Ações bioquímicas/fisiológicas

Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Pictogramas

Corrosion
GHS05

Palavra indicadora

Danger

Frases de perigo

H314

Classificações de perigo

Eye Dam. 1 - Skin Corr. 1B

Código de classe de armazenamento

8A - Combustible corrosive hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
BCCH2133
BCCF1322
BCCD2622
BCCC7995
BCCB2495

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Spermidine BioUltra, for molecular biology, ≥99.5% (GC)

Sigma-Aldrich

85558

Spermidine

Spermidine BioReagent, for molecular biology, suitable for cell culture, ≥98%

Sigma-Aldrich

S0266

Spermidine

Spermine tetrahydrochloride BioReagent, for molecular biology

Sigma-Aldrich

S1141

Spermine tetrahydrochloride

L-Ornithine monohydrochloride analytical standard

Supelco

57197

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Spermine tetrahydrochloride powder or crystals

Sigma-Aldrich

S2876

Spermine tetrahydrochloride

N8-Acetylspermidine dihydrochloride analytical standard

Supelco

A3658

N8-Acetylspermidine dihydrochloride

Spermine tetrahydrochloride BioUltra, for molecular biology, ≥99.5% (AT)

Sigma-Aldrich

85605

Spermine tetrahydrochloride

M Zhang et al.
Critical care medicine, 28(4 Suppl), N60-N66 (2000-05-12)
Spermine, a naturally occurring polyamine, is a ubiquitous structural component of all eukaryotic cells. Regenerating tissues produce higher levels of spermine, and injured or dying cells release spermine into the extracellular milieu, so that tissue levels increase significantly at inflammatory
Wendy Wai Yeng Yeo et al.
Journal of nanoscience and nanotechnology, 14(5), 3328-3336 (2014-04-17)
A nano-sized polymer, dextran-spermine (D-SPM), was shown to have the capacity to deliver gene to the lung of mouse via intranasal route. In this study, assessments on the safety profile of D-SPM were performed to complement the gene expression results.
Yoshiyuki Kubo et al.
Experimental eye research, 124, 17-23 (2014-05-20)
The elimination of spermine, the end product of cellular polyamine, from the retina to the blood across the blood-retinal barrier (BRB) was investigated. The in vivo microdialysis study revealed that the elimination of [(3)H]spermine from vitreous humor after vitreous bolus injection
An activity-dependent spermine-mediated mechanism that modulates glutamate transmission.
Domenico E Pellegrini-Giampietro
Trends in neurosciences, 26(1), 9-11 (2002-12-24)
R Amendola et al.
Current cancer drug targets, 9(2), 118-130 (2009-03-12)
The natural polyamines (PA), putrescine (PUT), spermidine (SPD) and spermine (SPM) are ubiquitous constituents of eukaryotic cells. The increase of PA in malignant and proliferating cells attracted the interest of scientists during last decades, addressing PA depletion as a new
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