21186

Calcium ionophore III

Selectophore^™, function tested

• Sinônimo(s): Calcium Ionophore A23187, Antibiotic A 23187, Calimycin
• Fórmula empírica (Notação de Hill): C₂₉H₃₇N₃O₆
• Número CAS: 52665-69-7
• Peso molecular: 523.62
• Beilstein: 1096801
• Número CE: 258-084-1
• Número MDL: MFCD00151202
• Código UNSPSC: 26111700
• ID de substância PubChem: 329752113
• NACRES: NB.61

Propriedades

• grau: for ion-selective electrodes
• Nível de qualidade: 200
• linha de produto: Selectophore^™
• forma: solid
• qualidade: function tested
• espectro de atividade do antibiótico: Gram-positive bacteria; fungi
• Modo de ação: cell membrane | interferes
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5
• InChI: 1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
• chave InChI: HIYAVKIYRIFSCZ-CYEMHPAKSA-N

Descrição

Descrição geral

Calcium ionophore III (Calimycin;CA) is a divalent cation ionophore. It has ability to transport Ca²⁺ ions across membranes along a concentration gradient.

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Aplicação

CA was used in elucidating the mechanisms underlying the positive and inotropic and chronotropic ability of CA on isolated superfused guinea pig atria. It may also be used to stimulate and measure the erythrocyte Ca²⁺ dependent K⁺ channels as the K⁺ efflux.

Calcium ionophore III may be used in ionophore-based calcium selective conductometric microsensors for the detection of calcium ions in aqueous solutions. In NIH3T3 and rat1-fibroblast cell cultures, calcium ionophore III along with thapsigargin has been reported to increase the hepatic clock gene Per1 expression in the initial period of treatment.

Ionophore highly selective for Ca²⁺. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Outras notas

Preparation of an optical chemical sensor for Ca²⁺ and Mg²⁺

Informações legais

Selectophore is a trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves