04725

3-Hydroxyglutaric acid

analytical standard

• Sinônimo(s): β-Hydroxyglutaric acid, 3-Hydroxypentanedioic acid
• Fórmula empírica (Notação de Hill): C₅H₈O₅
• Número CAS: 638-18-6
• Peso molecular: 148.11
• Beilstein: 1705476
• Número MDL: MFCD06208235
• Código UNSPSC: 12352106
• ID de substância PubChem: 329747978
• NACRES: NA.24

Propriedades

• grau: analytical standard
• Nível de qualidade: 100
• Ensaio: ≥95.0% (GC)
• prazo de validade: limited shelf life, expiry date on the label
• aplicação(ões): clinical testing
• formato: neat
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C5H8O5/c6-3(1-4(7)8)2-5(9)10/h3,6H,1-2H2,(H,7,8)(H,9,10)
• chave InChI: ZQHYXNSQOIDNTL-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

3-Hydroxyglutaric acid is a glutaric acid derivative which is the byproduct of glutaric acidemia type I. Glutaric aciduria type I (glutaryl-CoA dehydrogenase deficiency) is an inborn error of metabolism that usually manifests in infancy by an acute encephalopathic crisis and often results in permanent motor handicap. Studies indicate that 3-hydroxyglutaric acid can be used as biomarker for GCDH (glutaryl-CoA dehydrogenase) deficiency. It is believed that the excretion of 3-hydroxyglutaric acid is increased during ketosis, which occurs during glutaryl-CoA dehydrogenase deficiency. Studies on striatal cultures show that IGF-1 and FGF-2 (bFGF) reduces 3-hydroxyglutaric acid toxicity in striatal neurons.

Produtos recomendados

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Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3