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01467

Sigma-Aldrich

N1-Acetylspermine trihydrochloride

≥97.0% (TLC)

Sinônimo(s):

N-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]acetamide trihydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C12H28N4O · 3HCl
Número CAS:
77928-70-2
Peso molecular:
353.76
Beilstein:
7052482
Número MDL:
MFCD00083219
Código UNSPSC:
12352200
ID de substância PubChem:
329747292
NACRES:
NA.25

Nível de qualidade

100

Ensaio

≥97.0% (TLC)

cadeia de caracteres SMILES

Cl[H].Cl[H].Cl[H].CC(=O)NCCCNCCCCNCCCN

InChI

1S/C12H28N4O.3ClH/c1-12(17)16-11-5-10-15-8-3-2-7-14-9-4-6-13;;;/h14-15H,2-11,13H2,1H3,(H,16,17);3*1H

chave InChI

QQSPUTBJDXPUCR-UHFFFAOYSA-N

Aplicação

N1-Acetylspermine trihydrochloride has been used in a study to determine that the human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
BCBW6875
BCBW6912
BCBM4995V
BCBJ8286V
1382684V

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Spermine analytical standard

Supelco

55513

Spermine

Spermine ≥97%

Sigma-Aldrich

S3256

Spermine

Cadaverine dihydrochloride ~98%

Sigma-Aldrich

C8561

Cadaverine dihydrochloride

Spermidine ≥99% (GC)

Sigma-Aldrich

S2626

Spermidine

Masahiro Sugimoto et al.
Bio-protocol, 10(20), e3797-e3797 (2021-03-05)
Salivary metabolomics have provided the potentials to detect both oral and systemic diseases. Capillary electrophoresis time-of-flight-mass spectrometry (CE-TOFMS) enables the identification and quantification of various charged metabolites. This method has been employed to biomarker discoveries using human saliva samples, especially
Mustapha Aouida et al.
The Journal of biological chemistry, 285(9), 6275-6284 (2009-12-29)
Bleomycin is used in combination with other antineoplastic agents to effectively treat lymphomas, testicular carcinomas, and squamous cell carcinomas of the cervix, head, and neck. However, resistance to bleomycin remains a persistent limitation in exploiting the full therapeutic benefit of
Clara Meana et al.
Journal of cellular and molecular medicine, 20(2), 302-312 (2015-11-19)
Polyamines contribute to several physiological and pathological processes, including cardiac hypertrophy in experimental animals. This involves an increase in ornithine decarboxylase (ODC) activity and intracellular polyamines associated with cyclic adenosine monophosphate (cAMP) increases. The aim of the study was to
Leslie A Sandusky-Beltran et al.
The Journal of clinical investigation, 131(4) (2021-02-16)
Tauopathies display a spectrum of phenotypes from cognitive to affective behavioral impairments; however, mechanisms promoting tau pathology and how tau elicits behavioral impairment remain unclear. We report a unique interaction between polyamine metabolism, behavioral impairment, and tau fate. Polyamines are
Sarah van Veen et al.
Nature, 578(7795), 419-424 (2020-01-31)
ATP13A2 (PARK9) is a late endolysosomal transporter that is genetically implicated in a spectrum of neurodegenerative disorders, including Kufor-Rakeb syndrome-a parkinsonism with dementia1-and early-onset Parkinson's disease2. ATP13A2 offers protection against genetic and environmental risk factors of Parkinson's disease, whereas loss
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