SCT264
BioTracker™ Mitophagy Live Cell Probe
Human
Sinônimo(s):
mitochondrial degradation probe, mitophagy detection, mitophagy probe
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About This Item
Código UNSPSC:
41106514
NACRES:
NB.12
Produtos recomendados
Nome do produto
BioTracker™ Mitophagy Live Cell Probe,
fonte biológica
human
Nível de qualidade
Formulário
lyophilized solid
embalagem
vial of 15 μg
fabricante/nome comercial
Millipore
técnica(s)
cell culture | stem cell: suitable
Condições de expedição
2-8°C
temperatura de armazenamento
2-8°C
Descrição geral
The Mitophagy probe accumulates in intact mitochondria, where it is immobilized by chemical bonds and exhibits a weak fluorescence under normal conditions. When mitophagy is induced, the damaged mitochondria fuse with the lysosome, increasing fluorescence
SPECTRAL PROPERTIES
λex: 530 nm
λem: 700 nm
A 100 uM stock solution of the mitophagy probe is created by dissolving 50 uL DMSO to one tube (5 ug) of mitophagy dye.
A typical working solution concentration is 1 nM.
SPECTRAL PROPERTIES
λex: 530 nm
λem: 700 nm
A 100 uM stock solution of the mitophagy probe is created by dissolving 50 uL DMSO to one tube (5 ug) of mitophagy dye.
A typical working solution concentration is 1 nM.
Características e benefícios
SCT264 live cell mitophagy detection probe accumulates and is immobilized on intact mitochondria, which fuse to the lysosome after mitophagy is induced, causing the probe to fluoresce brightly. Mitophagy has been associated with the accumulation of dysfunctional mitochondria in diseases such Alzheimer′s and Parkinson′s.
Descrição-alvo
Mitochondria play an essential role in cells for the production of energy. Mitophagy, or the removal of damaged mitochondria via autophagy, has been connected to Alzheimer s and Parkinson s disease induced by the accumulation of depolarized mitochondria. Mitophagy serves as a dedicated elimination system that removes mitochondria whose dysfunction may be caused by oxidative stress and DNA damage. Mitochondria destined for autophagy are sequestered into the autophagosome, fused to the lysosome, and digested.
forma física
purple solid
Armazenamento e estabilidade
Store at 2 - 8 °C, protected from light.
Outras notas
This far red live cell probe for mitophagy detection fluoresces brightly when damaged mitochondria enter the acidic environment of the lysosome.
Informações legais
BioTracker is a trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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