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Merck
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Key Documents

MABN668

Sigma-Aldrich

Anti-Ly6C Antibody, clone 6C3

clone 6C3, from rat

Sinônimo(s):

Lymphocyte antigen 6C2, Ly-6C2

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rat

Nível de qualidade

100

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

6C3, monoclonal

reatividade de espécies

mouse

técnica(s)

dot blot: suitable
flow cytometry: suitable

Isotipo

IgG2aκ

nº de adesão NCBI

NP_001092687

nº de adesão UniProt

P0CW03

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

mouse ... Ly6C1(17067)

Descrição geral

Lymphocyte antigen 6C2 (Ly6C) is a 131 AA long membrane protein that is linked to macrophage phenotype according to expression levels.

Imunogênio

Whole cells expressing mouse Ly6C.

Aplicação

Detect Lymphocyte antigen 6C2 using this rat monoclonal antibody, Anti-Ly6C Antibody, clone 6C3 validated for use in Flow Cytometry & Dot Blot.
Dot Blot Analysis: A representative lot from an independent laboratory detected Ly6C in bone marrow-derived monocytes expressing 6C3 (Butovsky, O., et al. (2012). J Clin Invest. 122(9):3063-3087.).
Research Category
Neuroscience
Research Sub Category
Signaling Neuroscience

Qualidade

Evaluated by Flow Cytometry in mouse spleen cells.

Flow Cytometry Analysis: 1 µg of this antibody detected Ly6C in 1X10E6 mouse spleen cells.

Descrição-alvo

14 kDa calculated

forma física

Format: Purified
Protein G Purified
Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Zhilong Jiang et al.
Respiratory research, 18(1), 217-217 (2017-12-30)
SOCS3 (suppressor of cytokine signaling 3) is a negative regulator of JAK/STAT3 signaling pathway and participates in the regulation of lung inflammation in a mouse model with acute lung injury (ALI). However, it is not well understood how SOCS3 regulates
Qin Huang et al.
PloS one, 14(11), e0225206-e0225206 (2019-11-15)
The engineered AAV-PHP.B family of adeno-associated virus efficiently delivers genes throughout the mouse central nervous system. To guide their application across disease models, and to inspire the development of translational gene therapy vectors for targeting neurological diseases in humans, we
Oleg Butovsky et al.
The Journal of clinical investigation, 122(9), 3063-3087 (2012-08-07)
Amyotrophic lateral sclerosis (ALS) is a progressive disease associated with neuronal cell death that is thought to involve aberrant immune responses. Here we investigated the role of innate immunity in a mouse model of ALS. We found that inflammatory monocytes

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