MABC153
Anti-CKAP4 Antibody, clone 9C4.4
clone 9C4.4, from mouse
Sinônimo(s):
Cytoskeleton-associated protein 4, 63-kDa cytoskeleton-linking membrane protein, Climp-63, p63
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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Descrição geral
Cytoskeleton-associated protein 4, also known as 63-kDa cytoskeleton-linking membrane protein or Climp-63 or p63, and encoded by the gene CKAP4, is an integral membrane protein that links the endoplasmic reticulum (ER) to microtubules. The binding of CKAP4 is dependent upon its phosphorylation state: dephosphorylated CKAP4 binds microtubules and phosphorylated CKAP4 does not bind microtubules. CKAP4 is localized to the endoplasmic reticulum membrane and plasma membrane; CKAP4 is also found in the cytoplasm and perinuclear regions upon APF stimulation. CKAP4 is expressed is a wide variety of cell types and tissues and CKAP4 appears to be critical for antibiotic cytotoxicity for certain drugs like Gentamycin which bind the drug and cause CKAP4 to dimerize and malfunction.
Imunogênio
Epitope: coiled coil domain
GST-tagged recombinant protein corresponding to the coiled coil domain of human CKAP4.
Aplicação
Detect Cytoskeleton-associated protein 4 using this mouse monoclonal antibody, Anti-CKAP4 Antibody & clone 9C4.4 validated for use in western blotting.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Qualidade
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: 0.2 µg/mL of this antibody detected CKAP4 in 10 µg of HeLa cell lysate.
Western Blotting Analysis: 0.2 µg/mL of this antibody detected CKAP4 in 10 µg of HeLa cell lysate.
Descrição-alvo
~ 65 kDa observed. Uncharacterized band(s) may appear in some lysates.
forma física
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Armazenamento e estabilidade
Stable for 1 year at 2-8°C from date of receipt.
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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