SAB4200176

Anti-JNK antibody, Mouse monoclonal

clone 1C2, purified from hybridoma cell culture

• Sinônimo(s): Anti-JNK-46, Anti-JNK1, Anti-JNK1A2, Anti-JNK21B1/2, Anti-JUN N-terminal kinase, Anti-MAP kinase 8, Anti-MAPK8, Anti-PRKM8, Anti-SAPK1, Anti-stress-activated protein kinase 1
• Número MDL: MFCD00802809
• Código UNSPSC: 12352203
• NACRES: NA.44

Propriedades

• fonte biológica: mouse
• conjugado: unconjugated
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: 1C2, monoclonal
• peso molecular: antigen ~43 kDa
• reatividade de espécies: mouse, rat, human
• concentração: ~1.0 mg/mL
• técnica(s): western blot: 1-2 μg/mL using using whole extracts of mouse NIH-3T3 cells
• Isotipo: IgG2a
• nº de adesão UniProt: P45983
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... MAPK8(5599) ; mouse ... Mapk8(26419) ; rat ... Mapk8(116554)

Descrição

Descrição geral

Anti-JNK antibody, Mouse monoclonal, (mouse IgG2a isotype) is derived from the hybridoma 1C2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant protein. JNK1 (c-Jun N-terminal kinase), also known as MAPK8 (mitogen-activated protein kinase 8) is a member of the MAP kinase family. This gene is mapped to human chromosome 10q11.

Aplicação

Anti-JNK antibody, Mouse monoclonal has been used in immunoblotting and enzyme linked immunosorbent assay (ELISA).

Ações bioquímicas/fisiológicas

JNK1 (or MAPK8) is a serine threonine kinase that is a key regulator of cellular apoptosis. During the lack of NFkB stiμLation; persistent activation of JNK1 results in TNF-a induced cell death. However, JNK1 may also function as an apoptotic inhibitor. For instance; JNK1 interacts with WOX1 to inhibit apoptosis. Furthermore, JNK1 phosphorylates Bcl-2 to mediate starvation-induced autophagy, and also activates SIRT1 by phosphorylation during conditions of oxidative stress. JNK1 is activated by UV irradiation and oncoproteins and hence may be implicated in cancer propagation
Monoclonal Anti-JNK antibody is specific for human, mouse and rat JNK1 (43 kDa) and/or JNK2 (55 kDa).

JNK1 is also involved in UV (ultra violet) radiation induced apoptosis, which is thought to be related to cytochrome C-mediated cell death pathway.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable