MAB810R
Anti-Cytomegalovirus Antibody, clone 8B1.2
clone 8B1.2, Chemicon®, from mouse
Sinônimo(s):
CMV
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
8B1.2, monoclonal
reatividade de espécies
human
fabricante/nome comercial
Chemicon®
técnica(s)
ELISA: suitable
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
Isotipo
IgG2a
Condições de expedição
wet ice
Descrição geral
Human cytomegalovirus (HCMV) is a ubiquitous human pathogen that belongs to the herpes adenovirus family. The viral life cycle takes approximately seventy two hours. After the initial fusion of the viral envelope with the plasma membrane of the cell, the encapisidated virus particle is released into the cytoplasm and within minutes, transits to the nucleus. Via active transport through the nuclear pore, the capsid gains entry and viral DNA is deposited. Viral gene expression then occurs in a temporally regulated manner, first with expression of the immediate early genes, followed by the early genes, then, after viral replication has commenced, the late genes. All of the immediate early proteins have been shown to be transactivators, with IE1-72 and IE2-86 being the most well characterized. These genes regulate the expression of factors required for virus replication.
Especificidade
Reacts with an immediate early non-structural antigen of 68-72 kDa. This antigen can be detected 1 hour after infection exhibiting an intranuclear staining pattern. This staining reaches a peak at 10-12 hours. This antigen persists and can be detected throughout the complete CMV infection cycle.
Imunogênio
Affinity purified immediate early antigen from MRC-5 cells infected with CMV AD169 (ATCC).
Aplicação
Anti-Cytomegalovirus Antibody, clone 8B1.2 detects level of Cytomegalovirus & has been published & validated for use in ELISA, FC, IF, IH(P) & WB.
ELISA
Western Blot: 1:200. Recognizes approximately a 70kDa band.
Immunofluorescence: 1:200-1:400.
Immunohistochemistry 1:200-1:800.
Works on paraffin embedded tissue sections.
FACS
Optimal working dilutions must be determined by end user.
Western Blot: 1:200. Recognizes approximately a 70kDa band.
Immunofluorescence: 1:200-1:400.
Immunohistochemistry 1:200-1:800.
Works on paraffin embedded tissue sections.
FACS
Optimal working dilutions must be determined by end user.
Research Category
Infectious Diseases
Infectious Diseases
Research Sub Category
Infectious Diseases - Viral
Infectious Diseases - Viral
Descrição-alvo
68-72 kDa
forma física
Format: Purified
Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
Protein A purified
Armazenamento e estabilidade
Maintain for 1 year at 2–8°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Nota de análise
Control
Cytomegalovirus Control Slides, Catalogue Number 5027-5
Cytomegalovirus Control Slides, Catalogue Number 5027-5
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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No evidence of association between human cytomegalovirus infection and papillary thyroid cancer.
Huang, TS; Lee, JJ; Cheng, SP
World Journal of Surgical Oncology null
Jiri Bartek et al.
Molecular oncology, 11(8), 945-964 (2017-04-07)
Medulloblastomas are the most common, and often fatal, paediatric brain tumours that feature high genomic instability, frequent infection by human cytomegalovirus (HCMV) and resistance to radiation and chemotherapy. The causes of the pronounced chromosomal instability and its potential links with
Aldi Pupuleku et al.
Frontiers in immunology, 8, 1317-1317 (2017-11-09)
Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a mature NK cell subset, which displays high surface levels of the activating CD94/NKG2C NK cell receptor, together with additional distinctive phenotypic and functional features. The mechanisms underlying the
Human cytomegalovirus clinical strain-specific microRNA miR-UL148D targets the human chemokine RANTES during infection.
Kim, Y; Lee, S; Kim, S; Kim, D; Ahn, JH; Ahn, K
PLoS Pathogens null
Glycoprotein B (gB) vaccines adjuvanted with AS01 or AS02 protect female guinea pigs against cytomegalovirus (CMV) viremia and offspring mortality in a CMV-challenge model.
Schleiss, MR; Choi, KY; Anderson, J; Mash, JG; Wettendorff, M; Mossman, S; Van Damme, M
Vaccine null
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