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Documentos Principais

MAB805

Sigma-Aldrich

Anti-Adenovirus (Blend) Coating Antibody, clone 2/6, and 20/11

ascites fluid, Chemicon®, from mouse

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

forma do anticorpo

ascites fluid

clone

2/6, monoclonal
20/11, monoclonal

reatividade de espécies

human

fabricante/nome comercial

Chemicon®

técnica(s)

ELISA: suitable
immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

Isotipo

IgG1κ

Condições de expedição

wet ice

Descrição geral

Adenoviruses are 65-80 nm, non-enveloped, regular icosahedron pathogens often associated with respiratory and gastrointestinal illness as well as conjunctivitis. Well over 40 types of adenoviruses have currently been recognized. In addition to their deleterious effects, adenoviruses have been used in vaccine production and in gene therapy. They also have the ability to trigger cell proliferation by interfering with host cellular anti-oncogenes. Since they are easy to prepare, multiple quickly and efficiently, and have the ability to infect and deliver their genome (including researcher-created constructs) to the nucleus of a variety of post-mitotic cells, adenoviruses are extremely valuable in research and medical applications ranging from virus/host cell interaction to the insertion of novel genes or regulatory mechanisms into eukaryotic cellular systems, to delivery of therapeutic anti-cancer genes.

Especificidade

Reactive with all 41 serotypes of Adenovirus.

Imunogênio

Adeno 3

Aplicação

Anti-Adenovirus (Blend) Coating Antibody, clone 2/6 & 20/11 is an antibody against Adenovirus (Blend) Coating for use in ELISA, IF, IH, IH(P).
EIA: 1:1000

IFA: 1:200

Immunohistochemistry: 1:400 - 1:1000 for formalin fixed paraffin-embedded or frozen tissue.

Optimal working dilutions must be determined by end user.
Research Category
Infectious Diseases
Research Sub Category
Infectious Diseases - Viral

forma física

Ascites fluid containing no preservatives.
Unpurified

Armazenamento e estabilidade

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Nota de análise

Control
Adenovirus Control Slides, Catalogue Number 5009-5

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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Oncolytic virotherapy for prostate cancer by E1A, E1B mutant adenovirus.
Makoto Satoh, Hua Wang, Shigeto Ishidoya, Hisashi Abe, Takuya Moriya, Hirofumi Hamada, Yoichi Arai
Urology null
Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4.
Post, DE; Sandberg, EM; Kyle, MM; Devi, NS; Brat, DJ; Xu, Z; Tighiouart, M; Van Meir, EG
Cancer Research null
Li-xia Li et al.
Journal of translational medicine, 11, 257-257 (2013-10-16)
Gene therapy using a recombinant adenovirus (Ad) encoding secretory human endostatin (Ad-Endo) has been demonstrated to be a promising antiangiogenesis and antitumor strategy of in animal models and clinical trials. The E1B55KD-deficient Ad dl1520 was also found to replicate selectively
Anticancer efficacy of Apo2L/TRAIL is retained in the presence of high and biologically active concentrations of osteoprotegerin in vivo.
Zinonos I, Labrinidis A, Lee M, Liapis V, Hay S, Ponomarev V, Diamond P, Findlay DM et al.
Journal of Bone and Mineral Research null
Ran-Yi Liu et al.
Anatomical record (Hoboken, N.J. : 2007), 296(12), 1833-1841 (2013-10-19)
An E1B55K-attenuated adenovirus, dl1520, has been shown to replicate selectively in and lyse tumor cells. In this study, the antitumor activities of dl1520, alone or in combination with the chemotherapeutic agent cisplatin, were investigated in nasopharyngeal carcinoma (NPC) cells. The

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