CH2900011

Calcium Folinate Hydrate crystalline / Leucovorin Calcium crystalline

Ph. Eur., USP

• Sinônimo(s): Folinic acid calcium salt, Calcii Folinas, Calcium Folinate, Leucovorin Calcium, Calcium folinate
• Fórmula empírica (Notação de Hill): C₂₀H₂₁CaN₇O₇
• Número CAS: 1492-18-8
• Peso molecular: 511.50
• Código UNSPSC: 41116107

Propriedades

• fonte biológica: synthetic
• Nível de qualidade: 600
• grau: GMO free; GMP; Halal; Kosher
• Agency: Ph. Eur.; USP
• forma: powder
• aplicação(ões): pharmaceutical; solid formulation
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1
• chave InChI: KVUAALJSMIVURS-ZEDZUCNESA-L

Descrição

Descrição geral

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicação

Calcium Folinate Hydrate crystalline has three main clinical applications:
1) First line treatment for colorectal cancer: In combination with the anticancer drug 5-fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy.
2) Treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis as a rescue therapy to reduce the toxic side effects of intermediate or high doses of methotrexate.
3) Treatment of anemia caused by folate deficiency.

Embalagem

Customized packaging possible

Informações legais

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable