ABT121

Anti-T-cadherin (CDH13) Antibody

from rabbit, purified by affinity chromatography

• Sinônimo(s): Cadherin-13, Heart cadherin, H-cadherin, P105, Truncated cadherin, T-cad, T-cadherin
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• purificado por: affinity chromatography
• reatividade de espécies: horse, human, rat
• reatividade da espécie (prevista por homologia): mouse (based on 100% sequence homology), bovine (based on 100% sequence homology), equine (based on 100% sequence homology)
• técnica(s): immunohistochemistry: suitable (paraffin); western blot: suitable
• nº de adesão NCBI: NP_001248
• nº de adesão UniProt: P55290
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... CDH13(1012)

Descrição

Descrição geral

T-cadherin (CDH13), also known as Cadherin 13, is a member of the cadherin superfamily. This protein is unique from its other family members in that it lacks the cytoplasmic domains and is anchored to the cells membrane through the GPI anchor. T-cadherin is widely expressed in the cardiovascular system. Mutations in T-cadherin have been associated with many types of cancer.

Especificidade

This antibody recognizes T-cadherin at the Cadherin 1 domain. This antibody detects the ~130 kDa pro-protein and the proteolytically cleaved ~105 kDa mature isoforms. (Denzel, M., et al. (2010). J Clin Invest.120(12):4342–4352.)

Imunogênio

Epitope: Cadherin 1 domain

KLH-conjugated linear peptide corresponding to human T-cadherin at the Cadherin 1 domain.

Aplicação

Anti-T-cadherin (CDH13) Antibody detects level of T-cadherin (CDH13) & has been published & validated for use in WB, IH(P).

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected T-cadherin in human brain and human heart tissues.

Research Category
Cell Structure

Research Sub Category
Adhesion (CAMs)

Qualidade

Evaluated by Western Blot in human heart tissue lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected T-cadherin on 10 µg of human heart tissue lysate.

Descrição-alvo

~130 and ~105 kDa observed.
~130 kDa corresponds to the pro-protein and ~105 kDa corresponds to the proteolytically cleaved mature isoform. (Denzel, M., et al. (2010). J Clin Invest.120(12):4342–4352.)

forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Nota de análise

Control
Human heart tissue lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable